Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents
Introduction: in addition to genetic predisposition, a significant exogenous factor in the formation of Undifferentiated connective tissue dysplasia (UDCTD) is the deficiency of osteotropic micronutrients such as vitamins (D, A, C, E, K); macroelements (calcium, phosphorus, magnesium), trace...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2020-03-01
|
| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/5534 |
| _version_ | 1797841957414764544 |
|---|---|
| author | I. N. Zakharova T. M. Tvorogova E. А. Solov’yeva L. L. Stepurina A. S. Vorob’yeva |
| author_facet | I. N. Zakharova T. M. Tvorogova E. А. Solov’yeva L. L. Stepurina A. S. Vorob’yeva |
| author_sort | I. N. Zakharova |
| collection | DOAJ |
| description | Introduction: in addition to genetic predisposition, a significant exogenous factor in the formation of Undifferentiated connective tissue dysplasia (UDCTD) is the deficiency of osteotropic micronutrients such as vitamins (D, A, C, E, K); macroelements (calcium, phosphorus, magnesium), trace elements (copper, manganese, zinc, boron, selenium, silicon), so essential for the connective tissue matrix and, above all, for bone tissue. A small number of studies of osteotropic micronutrients and the state of bone tissue in adolescents with UDCTD served as the basis for this comprehensive study.Materials: a randomized study of 130 adolescents aged 10–16 years in the 1–2 health groups. The first group (primary) was 90 subjects with detected UDCTD. The second group (comparative) was 40 people with no signs of dysplasia. Methods: included the definition of: vitamin D – 25(ON)D: trace elements; calcium ductation: spinal column densitometry at LII–LIV level; physical development and psycho-emotional stress levels.Availability disorders of 25(OH)D, low calcium consumption, magnesium deficiency, and shifts in micronutrient content correlated with densitometric data showing a 75% decrease BMD in Group 1 adolescents, while in Group 2 only 27.5%.The results of a comprehensive study showed that osteotropic micronutrient deficiency is a serious exogenous trigger for the development and progression of UDCTD with osteopenia/osteoporosis formation. Osteopenia/osteoporosis, low physical development, disorders in the psycho-emotional sphere indicate the seriousness of the prognosis of UDCTD in adolescents. |
| first_indexed | 2024-04-09T16:39:54Z |
| format | Article |
| id | doaj.art-31c59d22e5b04cd3817c17743e8ff74c |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:39:54Z |
| publishDate | 2020-03-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-31c59d22e5b04cd3817c17743e8ff74c2023-04-23T06:56:44ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902020-03-0101304010.21518/2079-701X-2020-1-30-405034Connective tissue dysplasia: a risk factor for osteopenia in children and adolescentsI. N. Zakharova0T. M. Tvorogova1E. А. Solov’yeva2L. L. Stepurina3A. S. Vorob’yeva4Russian Medical Academy of Continuing Professional Education; Z.A. Bashlyaeva City Children’s Clinical HospitalRussian Medical Academy of Continuing Professional Education; Z.A. Bashlyaeva City Children’s Clinical HospitalRussian Medical Academy of Continuing Professional EducationRussian Medical Academy of Continuing Professional EducationZ.A. Bashlyaeva City Children’s Clinical HospitalIntroduction: in addition to genetic predisposition, a significant exogenous factor in the formation of Undifferentiated connective tissue dysplasia (UDCTD) is the deficiency of osteotropic micronutrients such as vitamins (D, A, C, E, K); macroelements (calcium, phosphorus, magnesium), trace elements (copper, manganese, zinc, boron, selenium, silicon), so essential for the connective tissue matrix and, above all, for bone tissue. A small number of studies of osteotropic micronutrients and the state of bone tissue in adolescents with UDCTD served as the basis for this comprehensive study.Materials: a randomized study of 130 adolescents aged 10–16 years in the 1–2 health groups. The first group (primary) was 90 subjects with detected UDCTD. The second group (comparative) was 40 people with no signs of dysplasia. Methods: included the definition of: vitamin D – 25(ON)D: trace elements; calcium ductation: spinal column densitometry at LII–LIV level; physical development and psycho-emotional stress levels.Availability disorders of 25(OH)D, low calcium consumption, magnesium deficiency, and shifts in micronutrient content correlated with densitometric data showing a 75% decrease BMD in Group 1 adolescents, while in Group 2 only 27.5%.The results of a comprehensive study showed that osteotropic micronutrient deficiency is a serious exogenous trigger for the development and progression of UDCTD with osteopenia/osteoporosis formation. Osteopenia/osteoporosis, low physical development, disorders in the psycho-emotional sphere indicate the seriousness of the prognosis of UDCTD in adolescents.https://www.med-sovet.pro/jour/article/view/5534connective tissue dysplasiaosteotropic micronutrientsosteopeniaosteoporosismacro- and microelementsvitamin d |
| spellingShingle | I. N. Zakharova T. M. Tvorogova E. А. Solov’yeva L. L. Stepurina A. S. Vorob’yeva Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents Медицинский совет connective tissue dysplasia osteotropic micronutrients osteopenia osteoporosis macro- and microelements vitamin d |
| title | Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents |
| title_full | Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents |
| title_fullStr | Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents |
| title_full_unstemmed | Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents |
| title_short | Connective tissue dysplasia: a risk factor for osteopenia in children and adolescents |
| title_sort | connective tissue dysplasia a risk factor for osteopenia in children and adolescents |
| topic | connective tissue dysplasia osteotropic micronutrients osteopenia osteoporosis macro- and microelements vitamin d |
| url | https://www.med-sovet.pro/jour/article/view/5534 |
| work_keys_str_mv | AT inzakharova connectivetissuedysplasiaariskfactorforosteopeniainchildrenandadolescents AT tmtvorogova connectivetissuedysplasiaariskfactorforosteopeniainchildrenandadolescents AT easolovyeva connectivetissuedysplasiaariskfactorforosteopeniainchildrenandadolescents AT llstepurina connectivetissuedysplasiaariskfactorforosteopeniainchildrenandadolescents AT asvorobyeva connectivetissuedysplasiaariskfactorforosteopeniainchildrenandadolescents |