Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer
Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-02-01
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| Series: | Genomics, Proteomics & Bioinformatics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672022916000371 |
| _version_ | 1797331467479547904 |
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| author | Yiwen Fang Melissa J. Fullwood |
| author_facet | Yiwen Fang Melissa J. Fullwood |
| author_sort | Yiwen Fang |
| collection | DOAJ |
| description | Long non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides. |
| first_indexed | 2024-03-08T07:35:00Z |
| format | Article |
| id | doaj.art-31ca6c1c43344b06ba200ba9285dc248 |
| institution | Directory Open Access Journal |
| issn | 1672-0229 |
| language | English |
| last_indexed | 2024-03-08T07:35:00Z |
| publishDate | 2016-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Genomics, Proteomics & Bioinformatics |
| spelling | doaj.art-31ca6c1c43344b06ba200ba9285dc2482024-02-02T19:03:39ZengElsevierGenomics, Proteomics & Bioinformatics1672-02292016-02-01141425410.1016/j.gpb.2015.09.006Roles, Functions, and Mechanisms of Long Non-coding RNAs in CancerYiwen Fang0Melissa J. Fullwood1Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeCancer Science Institute of Singapore, National University of Singapore, Singapore 117599, SingaporeLong non-coding RNAs (lncRNAs) play important roles in cancer. They are involved in chromatin remodeling, as well as transcriptional and post-transcriptional regulation, through a variety of chromatin-based mechanisms and via cross-talk with other RNA species. lncRNAs can function as decoys, scaffolds, and enhancer RNAs. This review summarizes the characteristics of lncRNAs, including their roles, functions, and working mechanisms, describes methods for identifying and annotating lncRNAs, and discusses future opportunities for lncRNA-based therapies using antisense oligonucleotides.http://www.sciencedirect.com/science/article/pii/S1672022916000371lncRNAsChromatinTranscription regulationAntisense oligonucleotidesCancer |
| spellingShingle | Yiwen Fang Melissa J. Fullwood Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer Genomics, Proteomics & Bioinformatics lncRNAs Chromatin Transcription regulation Antisense oligonucleotides Cancer |
| title | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer |
| title_full | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer |
| title_fullStr | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer |
| title_full_unstemmed | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer |
| title_short | Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer |
| title_sort | roles functions and mechanisms of long non coding rnas in cancer |
| topic | lncRNAs Chromatin Transcription regulation Antisense oligonucleotides Cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1672022916000371 |
| work_keys_str_mv | AT yiwenfang rolesfunctionsandmechanismsoflongnoncodingrnasincancer AT melissajfullwood rolesfunctionsandmechanismsoflongnoncodingrnasincancer |