Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications
The study of new metallic biomaterials for application in bone tissue repair has improved due to the increase in life expectancy and the aging of the world population. Titanium alloys are one of the main groups of biomaterials for these applications, and beta-type titanium alloys are more suitable f...
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MDPI AG
2022-12-01
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| Online Access: | https://www.mdpi.com/1996-1944/15/23/8636 |
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| author | João Pedro Aquiles Carobolante Adelvam Pereira Júnior Celso Bortolini Junior Kerolene Barboza da Silva Roberta Maia Sabino Ketul C. Popat Ana Paula Rosifini Alves Claro |
| author_facet | João Pedro Aquiles Carobolante Adelvam Pereira Júnior Celso Bortolini Junior Kerolene Barboza da Silva Roberta Maia Sabino Ketul C. Popat Ana Paula Rosifini Alves Claro |
| author_sort | João Pedro Aquiles Carobolante |
| collection | DOAJ |
| description | The study of new metallic biomaterials for application in bone tissue repair has improved due to the increase in life expectancy and the aging of the world population. Titanium alloys are one of the main groups of biomaterials for these applications, and beta-type titanium alloys are more suitable for long-term bone implants. The objective of this work was to process and characterize a new Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr beta alloy. Alloy processing involves arc melting, heat treatment, and cold forging. The characterization techniques used in this study were X-ray fluorescence spectroscopy, X-ray diffraction, differential scanning calorimetry, optical microscopy, microhardness measurements, and pulse excitation technique. In vitro studies using adipose-derived stem cells (ADSC) were performed to evaluate the cytotoxicity and cell viability after 1, 4, and 7 days. The results showed that the main phase during the processing route was the beta phase. At the end of processing, the alloy showed beta phase, equiaxed grains with an average size of 228.7 µm, and low Young’s modulus (83 GPa). In vitro studies revealed non-cytotoxicity and superior cell viability compared to CP Ti. The addition of zirconium led to a decrease in the beta-transus temperature and Young’s modulus and improved the biocompatibility of the alloy. Therefore, the Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr alloy is a promising candidate for application in the biomedical field. |
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| institution | Directory Open Access Journal |
| issn | 1996-1944 |
| language | English |
| last_indexed | 2024-03-09T17:41:27Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Materials |
| spelling | doaj.art-31cac6d2a2e248988e7fd7e214f0e30e2023-11-24T11:31:36ZengMDPI AGMaterials1996-19442022-12-011523863610.3390/ma15238636Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical ApplicationsJoão Pedro Aquiles Carobolante0Adelvam Pereira Júnior1Celso Bortolini Junior2Kerolene Barboza da Silva3Roberta Maia Sabino4Ketul C. Popat5Ana Paula Rosifini Alves Claro6School of Engineering and Sciences, Guaratinguetá Campus, São Paulo State University (Unesp), Guaratinguetá 12516-410, BrazilSchool of Engineering and Sciences, Guaratinguetá Campus, São Paulo State University (Unesp), Guaratinguetá 12516-410, BrazilSchool of Engineering and Sciences, Guaratinguetá Campus, São Paulo State University (Unesp), Guaratinguetá 12516-410, BrazilSchool of Engineering and Sciences, Guaratinguetá Campus, São Paulo State University (Unesp), Guaratinguetá 12516-410, BrazilSchool of Advanced Materials Discovery, Colorado State University, Fort Collins, CO 80523, USASchool of Advanced Materials Discovery, Colorado State University, Fort Collins, CO 80523, USASchool of Engineering and Sciences, Guaratinguetá Campus, São Paulo State University (Unesp), Guaratinguetá 12516-410, BrazilThe study of new metallic biomaterials for application in bone tissue repair has improved due to the increase in life expectancy and the aging of the world population. Titanium alloys are one of the main groups of biomaterials for these applications, and beta-type titanium alloys are more suitable for long-term bone implants. The objective of this work was to process and characterize a new Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr beta alloy. Alloy processing involves arc melting, heat treatment, and cold forging. The characterization techniques used in this study were X-ray fluorescence spectroscopy, X-ray diffraction, differential scanning calorimetry, optical microscopy, microhardness measurements, and pulse excitation technique. In vitro studies using adipose-derived stem cells (ADSC) were performed to evaluate the cytotoxicity and cell viability after 1, 4, and 7 days. The results showed that the main phase during the processing route was the beta phase. At the end of processing, the alloy showed beta phase, equiaxed grains with an average size of 228.7 µm, and low Young’s modulus (83 GPa). In vitro studies revealed non-cytotoxicity and superior cell viability compared to CP Ti. The addition of zirconium led to a decrease in the beta-transus temperature and Young’s modulus and improved the biocompatibility of the alloy. Therefore, the Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr alloy is a promising candidate for application in the biomedical field.https://www.mdpi.com/1996-1944/15/23/8636titanium alloysmechanical propertiesTi-Mo-Nb-Zrbiomaterial |
| spellingShingle | João Pedro Aquiles Carobolante Adelvam Pereira Júnior Celso Bortolini Junior Kerolene Barboza da Silva Roberta Maia Sabino Ketul C. Popat Ana Paula Rosifini Alves Claro Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications Materials titanium alloys mechanical properties Ti-Mo-Nb-Zr biomaterial |
| title | Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications |
| title_full | Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications |
| title_fullStr | Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications |
| title_full_unstemmed | Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications |
| title_short | Processing and Characterization of a New Quaternary Alloy Ti<sub>10</sub>Mo<sub>8</sub>Nb<sub>6</sub>Zr for Potential Biomedical Applications |
| title_sort | processing and characterization of a new quaternary alloy ti sub 10 sub mo sub 8 sub nb sub 6 sub zr for potential biomedical applications |
| topic | titanium alloys mechanical properties Ti-Mo-Nb-Zr biomaterial |
| url | https://www.mdpi.com/1996-1944/15/23/8636 |
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