Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells

Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells

Abstract Background Eosinophilic inflammation is a hallmark of refractory chronic rhinosinusitis (CRS) and considered a major therapeutic target. Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL‐1β overproduction, thereby suggesting autophagy reg...

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Bibliographic Details
Main Authors: Jinju Lee, So Jeong Kim, Go Eun Choi, Eunbi Yi, Hyo Jin Park, Woo Seon Choi, Yong Ju Jang, Hun Sik Kim
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Clinical and Translational Medicine
Subjects:
autophagy deficiency
chronic rhinosinusitis
eosinophilic inflammation
IL‐1β
macrophage
sweet taste receptor
Online Access:https://doi.org/10.1002/ctm2.1021

Internet

https://doi.org/10.1002/ctm2.1021

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