Prognostic significance of muc4 expression in gallbladder carcinoma
<p>Abstract</p> <p>Background</p> <p>Mucins are high molecular glycoproteins and play protective and lubricating roles in various epithelial tissues. Deregulated expression of mucins is involved in carcinogenesis and tumor invasion. MUC4 expression has been identified a...
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| Format: | Article |
| Language: | English |
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BMC
2012-10-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/224 |
| _version_ | 1819041239970873344 |
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| author | Lee Hyeon Cho Min-Sun Kim Tae |
| author_facet | Lee Hyeon Cho Min-Sun Kim Tae |
| author_sort | Lee Hyeon |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Mucins are high molecular glycoproteins and play protective and lubricating roles in various epithelial tissues. Deregulated expression of mucins is involved in carcinogenesis and tumor invasion. MUC4 expression has been identified as a poor prognostic factor in pancreatobiliary carcinomas. To date, the relation between MUC4 expression and prognosis in gallbladder carcinoma remains to be determined. Authors examined MUC4 expression in gallbladder carcinoma and investigated its impact on prognosis.</p> <p>Methods</p> <p>The expression profiles of MUC4, MUC1, MUC2 mucins in gallbladder carcinoma tissues from 63 patients were investigated using immunohistochemical staining.</p> <p>Results</p> <p>For gallbladder carcinoma, positive staining of MUC4, MUC1, and MUC2 was 55.6%, 81.0%, 28.6%, respectively. There was a significant correlation between the expression of MUC4 and the expression of MUC1 or MUC2 (p = 0.004, p = 0.009, respectively). Univariate analysis showed that MUC4 expression (p = 0.047), differentiation (p < 0.05), T-stage (p < 0.05) and lymph node metastasis (p < 0.001) were significantly associated with poor survival. Expression of MUC1 and MUC2 was not correlated to survival. The backward stepwise multivariate analysis showed that MUC4 expression (p = 0.039) and lymph node metastasis (p = 0.001) were significant independent risk factors. In combined assessment of MUC4 and MUC2 expression, MUC4 positive and MUC2 negative group showed a significantly worse outcome than MUC4 negative groups(MUC4-/MUC2+ and MUC4-/MUC2-) and MUC4/MUC2 co-expression group(MUC4+/MUC2+) (p < 0.05).</p> <p>Conclusions</p> <p>MUC4 expression in gallbladder carcinoma is an independent poor prognostic factor. Therefore, MUC4 expression may be a useful marker to predict the outcome of patients with surgically resected gallbladder carcinoma. MUC2 expression may have prognostic value when combined with MUC4 expression.</p> |
| first_indexed | 2024-12-21T09:21:51Z |
| format | Article |
| id | doaj.art-31cb7f569b3d4e6f8b180c5f4fe95791 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-21T09:21:51Z |
| publishDate | 2012-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-31cb7f569b3d4e6f8b180c5f4fe957912022-12-21T19:09:00ZengBMCWorld Journal of Surgical Oncology1477-78192012-10-0110122410.1186/1477-7819-10-224Prognostic significance of muc4 expression in gallbladder carcinomaLee HyeonCho Min-SunKim Tae<p>Abstract</p> <p>Background</p> <p>Mucins are high molecular glycoproteins and play protective and lubricating roles in various epithelial tissues. Deregulated expression of mucins is involved in carcinogenesis and tumor invasion. MUC4 expression has been identified as a poor prognostic factor in pancreatobiliary carcinomas. To date, the relation between MUC4 expression and prognosis in gallbladder carcinoma remains to be determined. Authors examined MUC4 expression in gallbladder carcinoma and investigated its impact on prognosis.</p> <p>Methods</p> <p>The expression profiles of MUC4, MUC1, MUC2 mucins in gallbladder carcinoma tissues from 63 patients were investigated using immunohistochemical staining.</p> <p>Results</p> <p>For gallbladder carcinoma, positive staining of MUC4, MUC1, and MUC2 was 55.6%, 81.0%, 28.6%, respectively. There was a significant correlation between the expression of MUC4 and the expression of MUC1 or MUC2 (p = 0.004, p = 0.009, respectively). Univariate analysis showed that MUC4 expression (p = 0.047), differentiation (p < 0.05), T-stage (p < 0.05) and lymph node metastasis (p < 0.001) were significantly associated with poor survival. Expression of MUC1 and MUC2 was not correlated to survival. The backward stepwise multivariate analysis showed that MUC4 expression (p = 0.039) and lymph node metastasis (p = 0.001) were significant independent risk factors. In combined assessment of MUC4 and MUC2 expression, MUC4 positive and MUC2 negative group showed a significantly worse outcome than MUC4 negative groups(MUC4-/MUC2+ and MUC4-/MUC2-) and MUC4/MUC2 co-expression group(MUC4+/MUC2+) (p < 0.05).</p> <p>Conclusions</p> <p>MUC4 expression in gallbladder carcinoma is an independent poor prognostic factor. Therefore, MUC4 expression may be a useful marker to predict the outcome of patients with surgically resected gallbladder carcinoma. MUC2 expression may have prognostic value when combined with MUC4 expression.</p>http://www.wjso.com/content/10/1/224MUC1MUC2MUC4Gallbladder carcinomaPrognosis |
| spellingShingle | Lee Hyeon Cho Min-Sun Kim Tae Prognostic significance of muc4 expression in gallbladder carcinoma World Journal of Surgical Oncology MUC1 MUC2 MUC4 Gallbladder carcinoma Prognosis |
| title | Prognostic significance of muc4 expression in gallbladder carcinoma |
| title_full | Prognostic significance of muc4 expression in gallbladder carcinoma |
| title_fullStr | Prognostic significance of muc4 expression in gallbladder carcinoma |
| title_full_unstemmed | Prognostic significance of muc4 expression in gallbladder carcinoma |
| title_short | Prognostic significance of muc4 expression in gallbladder carcinoma |
| title_sort | prognostic significance of muc4 expression in gallbladder carcinoma |
| topic | MUC1 MUC2 MUC4 Gallbladder carcinoma Prognosis |
| url | http://www.wjso.com/content/10/1/224 |
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