Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome

Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in SCN1A encoding the Nav1.1 sodium channel subunit, characterized by treatment-resistant epilepsy, temperature-sensitive seizures, developmental delay/intellectual disability with features of autism spectrum disorder,...

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Bibliographic Details
Main Authors: Joanna Mattis, Ala Somarowthu, Kevin M Goff, Evan Jiang, Jina Yom, Nathaniel Sotuyo, Laura M Mcgarry, Huijie Feng, Keisuke Kaneko, Ethan M Goldberg
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
Dravet syndrome
SCN1A
Nav1.1
gabaergic interneurons
dentate gyrus
Online Access:https://elifesciences.org/articles/69293

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