Changes in the Fecal Metabolome Accompany an Increase in Aberrant Crypt Foci in the Colon of C57BL/6 Mice Fed with a High-Fat Diet

Changes in the Fecal Metabolome Accompany an Increase in Aberrant Crypt Foci in the Colon of C57BL/6 Mice Fed with a High-Fat Diet

High-fat diet (HFD)-induced obesity is a risk factor for colon cancer. Our previous data show that compared to an AIN-93 diet (AIN), a HFD promotes azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF) formation and microbial dysbiosis in C57BL/6 mice. To explore the underlying metabolic basi...

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Bibliographic Details
Main Authors: Huawei Zeng, Bryan D. Safratowich, Wen-Hsing Cheng, Andrew D. Magnuson, Matthew J. Picklo
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Biomedicines
Subjects:
aberrant crypt foci
fatty acids
fecal metabolome
lipid
obesity
Online Access:https://www.mdpi.com/2227-9059/10/11/2891

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