Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria
Objective: a) to evaluate the appropriateness of histological criteria as proposed by Morson as indicators for surgery; and b) to compare the adequacy of Morson's criteria with Haggitt's levels as indicators for surgery in the case of malignant sessile lesions. Material and methods: we car...
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| Format: | Article |
| Language: | English |
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Aran Ediciones
2009-12-01
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| Series: | Revista Espanola de Enfermedades Digestivas |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009001200002 |
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| author | A. Pizarro-Moreno C. Cordero-Fernández M. Garzón-Benavides A. Cayuela J. M. Bozada-García S. Sobrino-Rodríguez T. López-Ruiz J. Caballero-Gómez T. Zulueta J. L. Márquez-Galán |
| author_facet | A. Pizarro-Moreno C. Cordero-Fernández M. Garzón-Benavides A. Cayuela J. M. Bozada-García S. Sobrino-Rodríguez T. López-Ruiz J. Caballero-Gómez T. Zulueta J. L. Márquez-Galán |
| author_sort | A. Pizarro-Moreno |
| collection | DOAJ |
| description | Objective: a) to evaluate the appropriateness of histological criteria as proposed by Morson as indicators for surgery; and b) to compare the adequacy of Morson's criteria with Haggitt's levels as indicators for surgery in the case of malignant sessile lesions. Material and methods: we carried out a prospective, protocolized study of 42 patients with polyps with invasive carcinoma (IC) who underwent colonoscopic polypectomy from 1979 through 2008. We applied the histological criteria proposed by Morson to all the patients included in the series. Results: we treated 24 polyps with IC and favorable histological criteria (FC) and 18 polyps showing unfavorable histological criteria (UC). All polyps with FC were treated by means of colonoscopic polypectomy. None of the patients showed signs of disease after a mean follow-up period o f 9.67 yrs. Patients with polyps with UC were recommended to undergo surgery. The presence of unfavorable histological criteria in the polypectomy sample was clearly associated with an unfavorable patient outcome and showed a 100% sensitivity level, a negative prognostic value (NPV) of 100%, and a false negative (FN) percentage of 0% for the prognosis of the disease. We found 12 sessile polyps (Haggitt's level 4). Colonoscopic polypectomy was the treatment employed in 9 out of 12 cases. All patients are free from disease (mean follow-up 7.3 yrs). If Haggitt's level criteria had been applied, all 12 patients would have undergone surgery. This means 58% more patients than following Morson's criteria. Conclusions: Morson's criteria are considered an adequate diagnostic tool for the indication of surgery in patients with malignant adenomas. Haggitt's invasion levels do not accurately discriminate the necessity for surgery in case of malignant sessile lesions. |
| first_indexed | 2024-04-13T21:09:14Z |
| format | Article |
| id | doaj.art-31cf4e2e2aca4b839ce0807305621980 |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-04-13T21:09:14Z |
| publishDate | 2009-12-01 |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-31cf4e2e2aca4b839ce08073056219802022-12-22T02:29:52ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082009-12-0110112830836Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitariaA. Pizarro-MorenoC. Cordero-FernándezM. Garzón-BenavidesA. CayuelaJ. M. Bozada-GarcíaS. Sobrino-RodríguezT. López-RuizJ. Caballero-GómezT. ZuluetaJ. L. Márquez-GalánObjective: a) to evaluate the appropriateness of histological criteria as proposed by Morson as indicators for surgery; and b) to compare the adequacy of Morson's criteria with Haggitt's levels as indicators for surgery in the case of malignant sessile lesions. Material and methods: we carried out a prospective, protocolized study of 42 patients with polyps with invasive carcinoma (IC) who underwent colonoscopic polypectomy from 1979 through 2008. We applied the histological criteria proposed by Morson to all the patients included in the series. Results: we treated 24 polyps with IC and favorable histological criteria (FC) and 18 polyps showing unfavorable histological criteria (UC). All polyps with FC were treated by means of colonoscopic polypectomy. None of the patients showed signs of disease after a mean follow-up period o f 9.67 yrs. Patients with polyps with UC were recommended to undergo surgery. The presence of unfavorable histological criteria in the polypectomy sample was clearly associated with an unfavorable patient outcome and showed a 100% sensitivity level, a negative prognostic value (NPV) of 100%, and a false negative (FN) percentage of 0% for the prognosis of the disease. We found 12 sessile polyps (Haggitt's level 4). Colonoscopic polypectomy was the treatment employed in 9 out of 12 cases. All patients are free from disease (mean follow-up 7.3 yrs). If Haggitt's level criteria had been applied, all 12 patients would have undergone surgery. This means 58% more patients than following Morson's criteria. Conclusions: Morson's criteria are considered an adequate diagnostic tool for the indication of surgery in patients with malignant adenomas. Haggitt's invasion levels do not accurately discriminate the necessity for surgery in case of malignant sessile lesions.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009001200002Malignant adenomasAdenomas with invasive carcinomaMorson's histological criteriaHaggitt's levels |
| spellingShingle | A. Pizarro-Moreno C. Cordero-Fernández M. Garzón-Benavides A. Cayuela J. M. Bozada-García S. Sobrino-Rodríguez T. López-Ruiz J. Caballero-Gómez T. Zulueta J. L. Márquez-Galán Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria Revista Espanola de Enfermedades Digestivas Malignant adenomas Adenomas with invasive carcinoma Morson's histological criteria Haggitt's levels |
| title | Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria |
| title_full | Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria |
| title_fullStr | Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria |
| title_full_unstemmed | Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria |
| title_short | Malignant colonic adenomas. Therapeutic criteria: Long-term results of therapy in a series of 42 patients in our healthcare area Adenomas malignos de colon. Criterios terapéticos: Resultados a largo plazo después de un tratamiento de una serie de 42 pacientes en nuestra área sanitaria |
| title_sort | malignant colonic adenomas therapeutic criteria long term results of therapy in a series of 42 patients in our healthcare area adenomas malignos de colon criterios terapeticos resultados a largo plazo despues de un tratamiento de una serie de 42 pacientes en nuestra area sanitaria |
| topic | Malignant adenomas Adenomas with invasive carcinoma Morson's histological criteria Haggitt's levels |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082009001200002 |
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