Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy
Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-01-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2020.621070/full |
| _version_ | 1828932704281821184 |
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| author | Jenniffer Linares Juan A. Marín-Jiménez Jordi Badia-Ramentol Alexandre Calon |
| author_facet | Jenniffer Linares Juan A. Marín-Jiménez Jordi Badia-Ramentol Alexandre Calon |
| author_sort | Jenniffer Linares |
| collection | DOAJ |
| description | Multiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology. |
| first_indexed | 2024-12-14T01:05:47Z |
| format | Article |
| id | doaj.art-31cf7569e8ae4a75a8c66e21f3ffe981 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-14T01:05:47Z |
| publishDate | 2021-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-31cf7569e8ae4a75a8c66e21f3ffe9812022-12-21T23:22:58ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-01-01810.3389/fcell.2020.621070621070Determinants and Functions of CAFs Secretome During Cancer Progression and TherapyJenniffer Linares0Juan A. Marín-Jiménez1Jordi Badia-Ramentol2Alexandre Calon3Cancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, SpainDepartment of Medical Oncology, Catalan Institute of Oncology (ICO) - L'Hospitalet de Llobregat, Barcelona, SpainCancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, SpainCancer Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, SpainMultiple lines of evidence are indicating that cancer development and malignant progression are not exclusively epithelial cancer cell-autonomous processes but may also depend on crosstalk with the surrounding tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundantly represented in the TME and are continuously interacting with cancer cells. CAFs are regulating key mechanisms during progression to metastasis and response to treatment by enhancing cancer cells survival and aggressiveness. The latest advances in CAFs biology are pointing to CAFs-secreted factors as druggable targets and companion tools for cancer diagnosis and prognosis. Especially, extensive research conducted in the recent years has underscored the potential of several cytokines as actionable biomarkers that are currently evaluated in the clinical setting. In this review, we explore the current understanding of CAFs secretome determinants and functions to discuss their clinical implication in oncology.https://www.frontiersin.org/articles/10.3389/fcell.2020.621070/fullcancer-associated fibroblast (CAF)secretomesecreted factorsgrowth factorscancertumor microenvironment (TME) |
| spellingShingle | Jenniffer Linares Juan A. Marín-Jiménez Jordi Badia-Ramentol Alexandre Calon Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy Frontiers in Cell and Developmental Biology cancer-associated fibroblast (CAF) secretome secreted factors growth factors cancer tumor microenvironment (TME) |
| title | Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy |
| title_full | Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy |
| title_fullStr | Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy |
| title_full_unstemmed | Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy |
| title_short | Determinants and Functions of CAFs Secretome During Cancer Progression and Therapy |
| title_sort | determinants and functions of cafs secretome during cancer progression and therapy |
| topic | cancer-associated fibroblast (CAF) secretome secreted factors growth factors cancer tumor microenvironment (TME) |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2020.621070/full |
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