Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive neurological disorder and the most common form of dementia worldwide. Sporadic Alzheimer’s disease (sAD) cases are the main forms, over 95% of AD cases, but still poorly understood. Thereby there is a crucial need to develop in vitro models for studying this...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
|
| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123002027 |
| _version_ | 1827776209838145536 |
|---|---|
| author | C. Clua Provost L. Auboyer A. Rovelet-Lecrux C. Monzo Eliot Schob S. Lehmann D. Wallon C. Crozet |
| author_facet | C. Clua Provost L. Auboyer A. Rovelet-Lecrux C. Monzo Eliot Schob S. Lehmann D. Wallon C. Crozet |
| author_sort | C. Clua Provost |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a progressive neurological disorder and the most common form of dementia worldwide. Sporadic Alzheimer’s disease (sAD) cases are the main forms, over 95% of AD cases, but still poorly understood. Thereby there is a crucial need to develop in vitro models for studying this multifactorial disorder. Here, we report the reprogramming of skin fibroblasts from a 57-years-old male donor. The new generated iPSC cell line has a normal karyotype and, is pluripotent since it demonstrates the ability to differentiate in vitro into the three germ layers. This iPSC line will be used to understand pathological mechanisms of sAD. |
| first_indexed | 2024-03-11T14:01:56Z |
| format | Article |
| id | doaj.art-31d12362aede4a849090005080ac9ea6 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-03-11T14:01:56Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-31d12362aede4a849090005080ac9ea62023-11-02T04:13:31ZengElsevierStem Cell Research1873-50612023-10-0172103216Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s diseaseC. Clua Provost0L. Auboyer1A. Rovelet-Lecrux2C. Monzo3Eliot Schob4S. Lehmann5D. Wallon6C. Crozet7INM, Univ Montpellier, INSERM, Montpellier, FranceInstitute for Regenerative Medicine and Biotherapy (IRMB), Univ Montpellier, INSERM, CHU Montpellier, Montpellier, FranceNormandie Univ, UNIROUEN, INSERM U1245, Rouen University Hospital, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, F 76000 Rouen, FranceINM, Univ Montpellier, INSERM, Montpellier, FranceINM, Univ Montpellier, INSERM, Montpellier, FranceINM, Univ Montpellier, INSERM, Montpellier, FranceNormandie Univ, UNIROUEN, INSERM U1245, Rouen University Hospital, Department of Neurology and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, F 76000 Rouen, FranceINM, Univ Montpellier, INSERM, Montpellier, France; Institute for Regenerative Medicine and Biotherapy (IRMB), Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France; Corresponding author.Alzheimer’s disease (AD) is a progressive neurological disorder and the most common form of dementia worldwide. Sporadic Alzheimer’s disease (sAD) cases are the main forms, over 95% of AD cases, but still poorly understood. Thereby there is a crucial need to develop in vitro models for studying this multifactorial disorder. Here, we report the reprogramming of skin fibroblasts from a 57-years-old male donor. The new generated iPSC cell line has a normal karyotype and, is pluripotent since it demonstrates the ability to differentiate in vitro into the three germ layers. This iPSC line will be used to understand pathological mechanisms of sAD.http://www.sciencedirect.com/science/article/pii/S1873506123002027 |
| spellingShingle | C. Clua Provost L. Auboyer A. Rovelet-Lecrux C. Monzo Eliot Schob S. Lehmann D. Wallon C. Crozet Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease Stem Cell Research |
| title | Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease |
| title_full | Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease |
| title_fullStr | Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease |
| title_full_unstemmed | Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease |
| title_short | Establishment of induced pluripotent stem cells IRMBi005-A from a patient with sporadic Alzheimer’s disease |
| title_sort | establishment of induced pluripotent stem cells irmbi005 a from a patient with sporadic alzheimer s disease |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123002027 |
| work_keys_str_mv | AT ccluaprovost establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT lauboyer establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT aroveletlecrux establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT cmonzo establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT eliotschob establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT slehmann establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT dwallon establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease AT ccrozet establishmentofinducedpluripotentstemcellsirmbi005afromapatientwithsporadicalzheimersdisease |