ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets

ATP-independent glucose stimulation of sphingosine kinase in rat pancreatic islets

Sphingosine kinase (SPHK) catalyzes sphingosine 1-phosphate production, promoting cell survival and reducing apoptosis in isolated rat pancreatic islets. Glucose, the primary islet β-cell growth factor and insulin secretagogue, increased islet SPHK activity by 3- to 5-fold following acute (1 h) or p...

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Bibliographic Details
Main Authors:	L.D. Mastrandrea, S.M. Sessanna, A. Del Toro, S.G. Laychock
Format:	Article
Language:	English
Published:	Elsevier 2010-08-01
Series:	Journal of Lipid Research
Subjects:	SPHK islets of Langerhans sphingosine-1-phosphate
Online Access:	http://www.sciencedirect.com/science/article/pii/S002222752037053X

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