Extracellular Prostaglandins E1 and E2 and Inflammatory Cytokines Are Regulated by the Senescence Program in Potentially Premalignant Oral Keratinocytes

Extracellular Prostaglandins E1 and E2 and Inflammatory Cytokines Are Regulated by the Senescence Program in Potentially Premalignant Oral Keratinocytes

Potentially pre-malignant oral lesions (PPOLs) are composed of keratinocytes that are either mortal (MPPOL) or immortal (IPPOL) in vitro. We report here that MPPOL, but not generally IPPOL, keratinocytes upregulate various extracellular tumor-promoting cytokines (interleukins 6 and 8) and prostaglan...

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Bibliographic Details
Main Authors: Lee Peng Karen-Ng, Usama Sharif Ahmad, Luis Gomes, Keith David Hunter, Hong Wan, Eleni Hagi-Pavli, Eric Kenneth Parkinson
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Cancers
Subjects:
oral
pre-malignancy
keratinocyte
cancer
senescence
p53
Online Access:https://www.mdpi.com/2072-6694/14/11/2636

Internet

https://www.mdpi.com/2072-6694/14/11/2636

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