A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development.
Patterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-09-01
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| Series: | PLoS Computational Biology |
| Online Access: | http://europepmc.org/articles/PMC5023109?pdf=render |
| _version_ | 1818180531337035776 |
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| author | Patrick Fried Máximo Sánchez-Aragón Daniel Aguilar-Hidalgo Birgitta Lehtinen Fernando Casares Dagmar Iber |
| author_facet | Patrick Fried Máximo Sánchez-Aragón Daniel Aguilar-Hidalgo Birgitta Lehtinen Fernando Casares Dagmar Iber |
| author_sort | Patrick Fried |
| collection | DOAJ |
| description | Patterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of the morphogenetic furrow (MF), a moving signaling wave that sweeps across the tissue from the posterior to the anterior side, that induces proliferating cells anterior to it to differentiate and become cell cycle quiescent in its wake. Therefore, final eye disc size depends on the proliferation rate of undifferentiated cells and on the speed with which the MF sweeps across the eye disc. We developed a spatio-temporal model of the growing eye disc based on the regulatory interactions controlled by the signals Decapentaplegic (Dpp), Hedgehog (Hh) and the transcription factor Homothorax (Hth) and explored how the signaling patterns affect the movement of the MF and impact on eye disc growth. We used published and new quantitative data to parameterize the model. In particular, two crucial parameter values, the degradation rate of Hth and the diffusion coefficient of Hh, were measured. The model is able to reproduce the linear movement of the MF and the termination of growth of the primordium. We further show that the model can explain several mutant phenotypes, but fails to reproduce the previously observed scaling of the Dpp gradient in the anterior compartment. |
| first_indexed | 2024-12-11T21:21:15Z |
| format | Article |
| id | doaj.art-31d3a690bb1848f9ac4cf46d94a04234 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-11T21:21:15Z |
| publishDate | 2016-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-31d3a690bb1848f9ac4cf46d94a042342022-12-22T00:50:27ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582016-09-01129e100505210.1371/journal.pcbi.1005052A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development.Patrick FriedMáximo Sánchez-AragónDaniel Aguilar-HidalgoBirgitta LehtinenFernando CasaresDagmar IberPatterning and growth are linked during early development and have to be tightly controlled to result in a functional tissue or organ. During the development of the Drosophila eye, this linkage is particularly clear: the growth of the eye primordium mainly results from proliferating cells ahead of the morphogenetic furrow (MF), a moving signaling wave that sweeps across the tissue from the posterior to the anterior side, that induces proliferating cells anterior to it to differentiate and become cell cycle quiescent in its wake. Therefore, final eye disc size depends on the proliferation rate of undifferentiated cells and on the speed with which the MF sweeps across the eye disc. We developed a spatio-temporal model of the growing eye disc based on the regulatory interactions controlled by the signals Decapentaplegic (Dpp), Hedgehog (Hh) and the transcription factor Homothorax (Hth) and explored how the signaling patterns affect the movement of the MF and impact on eye disc growth. We used published and new quantitative data to parameterize the model. In particular, two crucial parameter values, the degradation rate of Hth and the diffusion coefficient of Hh, were measured. The model is able to reproduce the linear movement of the MF and the termination of growth of the primordium. We further show that the model can explain several mutant phenotypes, but fails to reproduce the previously observed scaling of the Dpp gradient in the anterior compartment.http://europepmc.org/articles/PMC5023109?pdf=render |
| spellingShingle | Patrick Fried Máximo Sánchez-Aragón Daniel Aguilar-Hidalgo Birgitta Lehtinen Fernando Casares Dagmar Iber A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development. PLoS Computational Biology |
| title | A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development. |
| title_full | A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development. |
| title_fullStr | A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development. |
| title_full_unstemmed | A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development. |
| title_short | A Model of the Spatio-temporal Dynamics of Drosophila Eye Disc Development. |
| title_sort | model of the spatio temporal dynamics of drosophila eye disc development |
| url | http://europepmc.org/articles/PMC5023109?pdf=render |
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