Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report
There are various methods for treating advanced hepatocellular carcinoma with portal vein invasion, such as systemic chemotherapy, transarterial chemoembolization, transarterial radioembolization, and concurrent chemoradiotherapy. These methods have similar clinical efficacy but are designed with a...
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| Format: | Article |
| Language: | English |
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Korean Liver Cancer Association
2022-03-01
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| Series: | Journal of Liver Cancer |
| Subjects: | |
| Online Access: | http://e-jlc.org/upload/pdf/jlc-2022-03-07.pdf |
| _version_ | 1811311466181033984 |
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| author | In-Jung Kim Sung Hwan Yoo Jung Il Lee Kwan Sik Lee Hyun Woong Lee Jin Hong Lim |
| author_facet | In-Jung Kim Sung Hwan Yoo Jung Il Lee Kwan Sik Lee Hyun Woong Lee Jin Hong Lim |
| author_sort | In-Jung Kim |
| collection | DOAJ |
| description | There are various methods for treating advanced hepatocellular carcinoma with portal vein invasion, such as systemic chemotherapy, transarterial chemoembolization, transarterial radioembolization, and concurrent chemoradiotherapy. These methods have similar clinical efficacy but are designed with a palliative aim. Herein, we report a case that experienced complete remission through “associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)” after concurrent chemoradiotherapy and hepatic artery infusion chemotherapy. In this patient, concurrent chemoradiotherapy and hepatic artery infusion chemotherapy induced substantial tumor shrinkage, and hypertrophy of the nontumor liver was sufficiently induced by portal vein ligation (stage 1 surgery) followed by curative resection (stage 2 surgery). Using this approach, long-term survival with no evidence of recurrence was achieved at 16 months. Therefore, the optimal use of ALPPS requires sufficient consideration in cases of significant hepatocellular carcinoma shrinkage for curative purposes. |
| first_indexed | 2024-04-13T10:19:23Z |
| format | Article |
| id | doaj.art-31d44e49e2914bc8b0a0c138bdaf2a3b |
| institution | Directory Open Access Journal |
| issn | 2288-8128 2383-5001 |
| language | English |
| last_indexed | 2024-04-13T10:19:23Z |
| publishDate | 2022-03-01 |
| publisher | Korean Liver Cancer Association |
| record_format | Article |
| series | Journal of Liver Cancer |
| spelling | doaj.art-31d44e49e2914bc8b0a0c138bdaf2a3b2022-12-22T02:50:33ZengKorean Liver Cancer AssociationJournal of Liver Cancer2288-81282383-50012022-03-01221849010.17998/jlc.2022.03.07495Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case reportIn-Jung Kim0Sung Hwan Yoo1Jung Il Lee2Kwan Sik Lee3Hyun Woong Lee4Jin Hong Lim5 Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, KoreaThere are various methods for treating advanced hepatocellular carcinoma with portal vein invasion, such as systemic chemotherapy, transarterial chemoembolization, transarterial radioembolization, and concurrent chemoradiotherapy. These methods have similar clinical efficacy but are designed with a palliative aim. Herein, we report a case that experienced complete remission through “associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)” after concurrent chemoradiotherapy and hepatic artery infusion chemotherapy. In this patient, concurrent chemoradiotherapy and hepatic artery infusion chemotherapy induced substantial tumor shrinkage, and hypertrophy of the nontumor liver was sufficiently induced by portal vein ligation (stage 1 surgery) followed by curative resection (stage 2 surgery). Using this approach, long-term survival with no evidence of recurrence was achieved at 16 months. Therefore, the optimal use of ALPPS requires sufficient consideration in cases of significant hepatocellular carcinoma shrinkage for curative purposes.http://e-jlc.org/upload/pdf/jlc-2022-03-07.pdfcarcinomahepatocellularportal veinhepatectomyconcurrent chemoradiotherapycase reports |
| spellingShingle | In-Jung Kim Sung Hwan Yoo Jung Il Lee Kwan Sik Lee Hyun Woong Lee Jin Hong Lim Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report Journal of Liver Cancer carcinoma hepatocellular portal vein hepatectomy concurrent chemoradiotherapy case reports |
| title | Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report |
| title_full | Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report |
| title_fullStr | Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report |
| title_full_unstemmed | Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report |
| title_short | Long-term survival after CCRT and HAIC followed by ALPPS for hepatocellular carcinoma with portal vein invasion: a case report |
| title_sort | long term survival after ccrt and haic followed by alpps for hepatocellular carcinoma with portal vein invasion a case report |
| topic | carcinoma hepatocellular portal vein hepatectomy concurrent chemoradiotherapy case reports |
| url | http://e-jlc.org/upload/pdf/jlc-2022-03-07.pdf |
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