Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations
Sialylated oligosaccharides, including 3ˊ-sialyllactose (3ˊ-SL) and 6ˊ-sialyllactose (6ˊ-SL), comprise a large portion of human milk and have been known to support development over the first year of life. While research has investigated the impact of early-life supplementation, longer-term supplemen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1278804/full |
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| author | Rebecca K. Golden Loretta T. Sutkus Laura L. Bauer Sharon M. Donovan Sharon M. Donovan Ryan N. Dilger Ryan N. Dilger Ryan N. Dilger |
| author_facet | Rebecca K. Golden Loretta T. Sutkus Laura L. Bauer Sharon M. Donovan Sharon M. Donovan Ryan N. Dilger Ryan N. Dilger Ryan N. Dilger |
| author_sort | Rebecca K. Golden |
| collection | DOAJ |
| description | Sialylated oligosaccharides, including 3ˊ-sialyllactose (3ˊ-SL) and 6ˊ-sialyllactose (6ˊ-SL), comprise a large portion of human milk and have been known to support development over the first year of life. While research has investigated the impact of early-life supplementation, longer-term supplementation remains relatively unexplored. Consequently, the following study assesses the impact of supplementation of either 3ˊ-SL or 6ˊ-SL on growth performance, tolerance, and brain sialic acid concentrations. Two-day-old piglets (n = 75) were randomly assigned to a commercial milk replacer ad libitum without or with 3ˊ-SL or 6ˊ-SL (added at 0.2673% on an as-is basis). Daily body weight and feed disappearance were recorded to assess growth performance and tolerance. Pigs were euthanized for sample collection on postnatal day 33 (n = 30) or 61 (n = 33), respectively. Across growth performance, clinical chemistry and hematology, histomorphology, and sialic acid quantification, dietary differences were largely unremarkable at either time-point. Overall, SA was well-tolerated both short-term and long-term. |
| first_indexed | 2024-03-11T17:23:23Z |
| format | Article |
| id | doaj.art-31d4baa4a3d048f2abf69dc0f8101e59 |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-11T17:23:23Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-31d4baa4a3d048f2abf69dc0f8101e592023-10-19T07:16:42ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-10-011010.3389/fnut.2023.12788041278804Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrationsRebecca K. Golden0Loretta T. Sutkus1Laura L. Bauer2Sharon M. Donovan3Sharon M. Donovan4Ryan N. Dilger5Ryan N. Dilger6Ryan N. Dilger7Neuroscience Program, University of Illinois, Urbana, IL, United StatesNeuroscience Program, University of Illinois, Urbana, IL, United StatesDepartment of Animal Sciences, University of Illinois, Urbana, IL, United StatesDepartment of Food Science and Human Nutrition, University of Illinois, Urbana, IL, United StatesDivision of Nutritional Sciences, University of Illinois, Urbana, IL, United StatesNeuroscience Program, University of Illinois, Urbana, IL, United StatesDepartment of Animal Sciences, University of Illinois, Urbana, IL, United StatesDivision of Nutritional Sciences, University of Illinois, Urbana, IL, United StatesSialylated oligosaccharides, including 3ˊ-sialyllactose (3ˊ-SL) and 6ˊ-sialyllactose (6ˊ-SL), comprise a large portion of human milk and have been known to support development over the first year of life. While research has investigated the impact of early-life supplementation, longer-term supplementation remains relatively unexplored. Consequently, the following study assesses the impact of supplementation of either 3ˊ-SL or 6ˊ-SL on growth performance, tolerance, and brain sialic acid concentrations. Two-day-old piglets (n = 75) were randomly assigned to a commercial milk replacer ad libitum without or with 3ˊ-SL or 6ˊ-SL (added at 0.2673% on an as-is basis). Daily body weight and feed disappearance were recorded to assess growth performance and tolerance. Pigs were euthanized for sample collection on postnatal day 33 (n = 30) or 61 (n = 33), respectively. Across growth performance, clinical chemistry and hematology, histomorphology, and sialic acid quantification, dietary differences were largely unremarkable at either time-point. Overall, SA was well-tolerated both short-term and long-term.https://www.frontiersin.org/articles/10.3389/fnut.2023.1278804/fullgrowthhematologyhistomorphologysialic acid3ˊ-sialyllactose6ˊ-sialyllactose |
| spellingShingle | Rebecca K. Golden Loretta T. Sutkus Laura L. Bauer Sharon M. Donovan Sharon M. Donovan Ryan N. Dilger Ryan N. Dilger Ryan N. Dilger Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations Frontiers in Nutrition growth hematology histomorphology sialic acid 3ˊ-sialyllactose 6ˊ-sialyllactose |
| title | Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations |
| title_full | Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations |
| title_fullStr | Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations |
| title_full_unstemmed | Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations |
| title_short | Determining the safety and efficacy of dietary supplementation with 3ˊ-sialyllactose or 6ˊ-sialyllactose on growth, tolerance, and brain sialic acid concentrations |
| title_sort | determining the safety and efficacy of dietary supplementation with 3ˊ sialyllactose or 6ˊ sialyllactose on growth tolerance and brain sialic acid concentrations |
| topic | growth hematology histomorphology sialic acid 3ˊ-sialyllactose 6ˊ-sialyllactose |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1278804/full |
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