Discovery of Novel Boron-Containing <em>N</em>-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

Discovery of Novel Boron-Containing <em>N</em>-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

To address drug resistance to influenza virus neuraminidase inhibitors (NAIs), a series of novel boron-containing <i>N</i>-substituted oseltamivir derivatives were designed and synthesized to target the 150-cavity of neuraminidase (NA). In NA inhibitory assays, it was found that most of...

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Bibliographic Details
Main Authors: Ruifang Jia, Jiwei Zhang, Jian Zhang, Chiara Bertagnin, Anna Bonomini, Laura Guizzo, Zhen Gao, Xiangkai Ji, Zhuo Li, Chuanfeng Liu, Han Ju, Xiuli Ma, Arianna Loregian, Bing Huang, Peng Zhan, Xinyong Liu
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
influenza
neuraminidase inhibitors
oseltamivir derivatives
150-cavity
boronic acid
Online Access:https://www.mdpi.com/1420-3049/27/19/6426

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