Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis
Kikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is more common in young women and typically presents with small, painful, localized cervical lymphadenopathy that resolves spontaneously within a few weeks. Laboratory findings are variable. As many as 40% of KFD case...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2024-01-01
|
| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/4258 |
| _version_ | 1797320613102092288 |
|---|---|
| author | Mutsuka Kurihara Yasutaka Yanagita Daiki Yokokawa Yu Li Masatomi Ikusaka |
| author_facet | Mutsuka Kurihara Yasutaka Yanagita Daiki Yokokawa Yu Li Masatomi Ikusaka |
| author_sort | Mutsuka Kurihara |
| collection | DOAJ |
| description | Kikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is more common in young women and typically presents with small, painful, localized cervical lymphadenopathy that resolves spontaneously within a few weeks. Laboratory findings are variable. As many as 40% of KFD cases are reported to be painless, and up to 22% to be generalized lymphadenopathy. Therefore, malignant lymphoma could be a differential diagnosis of KFD. A histopathologic diagnosis is needed when it is difficult to distinguish KFD from lymphoma. KFD typically shows small, highly accumulated cervical lymph nodes on fluorodeoxyglucose positron emission tomography (FDG-PET). This contrasts with malignant lymphoma, which tends to be associated with massive lymphadenopathy. In our case, a 40-year-old Japanese male presented with painless lumps in the right neck, accompanied by fever, night sweats, and loss of appetite. His symptoms and laboratory results worsened over a month. FDG-PET revealed highly accumulated uptake in cervical, mediastinal, and axillary lymph nodes. The PET imaging showed a small, high FDG uptake and contributed to the correct diagnosis of KFD. This case report highlights the importance of FDG-PET, which is a valuable diagnostic tool for KFD as it typically differentiates large clusters of small lymph nodes typical of KFD from normal lymph nodes. |
| first_indexed | 2024-03-08T04:44:35Z |
| format | Article |
| id | doaj.art-31d673dbcd514923a0efea13496c28aa |
| institution | Directory Open Access Journal |
| issn | 2284-2594 |
| language | English |
| last_indexed | 2024-03-08T04:44:35Z |
| publishDate | 2024-01-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj.art-31d673dbcd514923a0efea13496c28aa2024-02-08T10:55:15ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942024-01-0110.12890/2024_0042583793Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosisMutsuka Kurihara0Yasutaka Yanagita1Daiki Yokokawa2Yu Li3Masatomi Ikusaka4Department of General Medicine, Chiba University Hospital, Chiba, JapanDepartment of General Medicine, Chiba University Hospital, Chiba, JapanDepartment of General Medicine, Chiba University Hospital, Chiba, JapanDepartment of General Medicine, Chiba University Hospital, Chiba, JapanDepartment of General Medicine, Chiba University Hospital, Chiba, JapanKikuchi-Fujimoto disease (KFD), also called histiocytic necrotizing lymphadenitis, is more common in young women and typically presents with small, painful, localized cervical lymphadenopathy that resolves spontaneously within a few weeks. Laboratory findings are variable. As many as 40% of KFD cases are reported to be painless, and up to 22% to be generalized lymphadenopathy. Therefore, malignant lymphoma could be a differential diagnosis of KFD. A histopathologic diagnosis is needed when it is difficult to distinguish KFD from lymphoma. KFD typically shows small, highly accumulated cervical lymph nodes on fluorodeoxyglucose positron emission tomography (FDG-PET). This contrasts with malignant lymphoma, which tends to be associated with massive lymphadenopathy. In our case, a 40-year-old Japanese male presented with painless lumps in the right neck, accompanied by fever, night sweats, and loss of appetite. His symptoms and laboratory results worsened over a month. FDG-PET revealed highly accumulated uptake in cervical, mediastinal, and axillary lymph nodes. The PET imaging showed a small, high FDG uptake and contributed to the correct diagnosis of KFD. This case report highlights the importance of FDG-PET, which is a valuable diagnostic tool for KFD as it typically differentiates large clusters of small lymph nodes typical of KFD from normal lymph nodes.https://www.ejcrim.com/index.php/EJCRIM/article/view/4258type a aortic dissectionbentall procedureatypical symptoms |
| spellingShingle | Mutsuka Kurihara Yasutaka Yanagita Daiki Yokokawa Yu Li Masatomi Ikusaka Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis European Journal of Case Reports in Internal Medicine type a aortic dissection bentall procedure atypical symptoms |
| title | Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis |
| title_full | Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis |
| title_fullStr | Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis |
| title_full_unstemmed | Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis |
| title_short | Atypical Kikuchi-Fujimoto disease: FDG-PET contribution to the diagnosis |
| title_sort | atypical kikuchi fujimoto disease fdg pet contribution to the diagnosis |
| topic | type a aortic dissection bentall procedure atypical symptoms |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/4258 |
| work_keys_str_mv | AT mutsukakurihara atypicalkikuchifujimotodiseasefdgpetcontributiontothediagnosis AT yasutakayanagita atypicalkikuchifujimotodiseasefdgpetcontributiontothediagnosis AT daikiyokokawa atypicalkikuchifujimotodiseasefdgpetcontributiontothediagnosis AT yuli atypicalkikuchifujimotodiseasefdgpetcontributiontothediagnosis AT masatomiikusaka atypicalkikuchifujimotodiseasefdgpetcontributiontothediagnosis |