Microvessel density in the placental bed among preeclampsia patients
CONTEXT AND OBJECTIVE: Morphological changes in the spiral arteries of the placental bed have been studied in patients with preeclampsia, one of the largest causes of maternal and perinatal morbidity and mortality. The reports show that vasospasm and vascular endothelial injury were two major pathol...
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
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| Series: | São Paulo Medical Journal |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000200009&lng=en&tlng=en |
| _version_ | 1818540253106929664 |
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| author | Tarcisio Mota Coelho Nelson Sass Luiz Camano Antonio Fernandes Moron Rosiane Mattar João Noberto Stávale Maria Regina Régis Silva Marília da Glória Martins João Nogueira Neto |
| author_facet | Tarcisio Mota Coelho Nelson Sass Luiz Camano Antonio Fernandes Moron Rosiane Mattar João Noberto Stávale Maria Regina Régis Silva Marília da Glória Martins João Nogueira Neto |
| author_sort | Tarcisio Mota Coelho |
| collection | DOAJ |
| description | CONTEXT AND OBJECTIVE: Morphological changes in the spiral arteries of the placental bed have been studied in patients with preeclampsia, one of the largest causes of maternal and perinatal morbidity and mortality. The reports show that vasospasm and vascular endothelial injury were two major pathological conditions for preeclampsia. The aim of this study was to investigate the microvessel density of spiral arteries in the placental bed, in pregnancies complicated by hypertension and proteinuria, and in normal pregnancies. DESIGN AND SETTING: This was a cross-sectional survey of immunohistochemical studies on biopsies from the spiral arteries of the placental bed, among women undergoing cesarean sections for clinical and obstetrical reasons at Universidade Federal de São Paulo, São Paulo, Brazil. METHODS: Placental bed biopsies were obtained during cesarean section after placenta removal, with direct viewing of the central area of placenta insertion. The microvessel density of spiral arteries was measured by immunohistochemical methods in decidual and myometrial segments, using CD34 antibody. RESULTS: Biopsies containing spiral arteries were obtained from 34 hypertensive pregnant women with proteinuria, and 26 normotensive pregnant women. The microvessel densities in decidual and myometrial segments of the placental bed were compared between the groups. It was observed that, with increasing blood pressure and proteinuria, the microvessel density gradually decreased. CONCLUSION: The presence of high levels of hypertension and proteinuria may be associated with a progressive decrease in microvessel density in the placental bed. |
| first_indexed | 2024-12-11T21:52:54Z |
| format | Article |
| id | doaj.art-31d7a0b47a904f0094531dadb9d3d37b |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-11T21:52:54Z |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-31d7a0b47a904f0094531dadb9d3d37b2022-12-22T00:49:25ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-946012429610010.1590/S1516-31802006000200009S1516-31802006000200009Microvessel density in the placental bed among preeclampsia patientsTarcisio Mota Coelho0Nelson Sass1Luiz Camano2Antonio Fernandes Moron3Rosiane Mattar4João Noberto Stávale5Maria Regina Régis Silva6Marília da Glória Martins7João Nogueira Neto8Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal do MaranhãoUniversidade Federal do MaranhãoCONTEXT AND OBJECTIVE: Morphological changes in the spiral arteries of the placental bed have been studied in patients with preeclampsia, one of the largest causes of maternal and perinatal morbidity and mortality. The reports show that vasospasm and vascular endothelial injury were two major pathological conditions for preeclampsia. The aim of this study was to investigate the microvessel density of spiral arteries in the placental bed, in pregnancies complicated by hypertension and proteinuria, and in normal pregnancies. DESIGN AND SETTING: This was a cross-sectional survey of immunohistochemical studies on biopsies from the spiral arteries of the placental bed, among women undergoing cesarean sections for clinical and obstetrical reasons at Universidade Federal de São Paulo, São Paulo, Brazil. METHODS: Placental bed biopsies were obtained during cesarean section after placenta removal, with direct viewing of the central area of placenta insertion. The microvessel density of spiral arteries was measured by immunohistochemical methods in decidual and myometrial segments, using CD34 antibody. RESULTS: Biopsies containing spiral arteries were obtained from 34 hypertensive pregnant women with proteinuria, and 26 normotensive pregnant women. The microvessel densities in decidual and myometrial segments of the placental bed were compared between the groups. It was observed that, with increasing blood pressure and proteinuria, the microvessel density gradually decreased. CONCLUSION: The presence of high levels of hypertension and proteinuria may be associated with a progressive decrease in microvessel density in the placental bed.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000200009&lng=en&tlng=enPre-eclampsiaProteinuriaTrophoblastsEndotheliumEndothelins |
| spellingShingle | Tarcisio Mota Coelho Nelson Sass Luiz Camano Antonio Fernandes Moron Rosiane Mattar João Noberto Stávale Maria Regina Régis Silva Marília da Glória Martins João Nogueira Neto Microvessel density in the placental bed among preeclampsia patients São Paulo Medical Journal Pre-eclampsia Proteinuria Trophoblasts Endothelium Endothelins |
| title | Microvessel density in the placental bed among preeclampsia patients |
| title_full | Microvessel density in the placental bed among preeclampsia patients |
| title_fullStr | Microvessel density in the placental bed among preeclampsia patients |
| title_full_unstemmed | Microvessel density in the placental bed among preeclampsia patients |
| title_short | Microvessel density in the placental bed among preeclampsia patients |
| title_sort | microvessel density in the placental bed among preeclampsia patients |
| topic | Pre-eclampsia Proteinuria Trophoblasts Endothelium Endothelins |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802006000200009&lng=en&tlng=en |
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