Sexual dimorphism in reactive oxygen species production and a role for integrin α1β1 in estrogen receptor α and β expression in articular cartilage

Sexual dimorphism in reactive oxygen species production and a role for integrin α1β1 in estrogen receptor α and β expression in articular cartilage

Abstract Background Osteoarthritis (OA) is a debilitating disease involving cartilage degradation. A need remains for the discovery of new molecular targets in cartilage for pharmaceutical intervention of OA. One potential target is integrin α1β1 that protects against OA when it is upregulated by ch...

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Bibliographic Details
Main Authors: Alicia L. Black, James Haskins, Ambra Pozzi, Andrea L. Clark
Format: Article
Language:English
Published: BMC 2023-03-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Integrins
Epidermal growth factor receptor
Estrogen receptor alpha
Estrogen receptor beta
Chondrocyte
Articular cartilage
Online Access:https://doi.org/10.1186/s13018-023-03655-2

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