Insulin-like growth factor-1 levels in children with Beta-thalassemia minor
Objective: Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and hypermetabolism. It has also been proven that growth retard...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2008-09-01
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| Series: | Turkish Journal of Hematology |
| Subjects: | |
| Online Access: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-35119 |
| _version_ | 1797918411397791744 |
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| author | Mehran Karimi Hamdollah Karamifar Nargrs Sobhani |
| author_facet | Mehran Karimi Hamdollah Karamifar Nargrs Sobhani |
| author_sort | Mehran Karimi |
| collection | DOAJ |
| description | Objective: Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and hypermetabolism. It has also been proven that growth retardation is present in b-thalassemia major children despite regular transfusion and chelation. Our aim was to evaluate the level of IGF-1 in b-thalassemia minor subjects and compare it with that in healthy children. Material and Methods: Fifty children aged 6 months to 15 years with b-thalassemia minor (32 males, 18 females) and 50 age- and sex-matched normal healthy children were selected. Medical history was taken and complete physical examination was done in each case; IGF-1 level was checked in all cases. This study was done in Shiraz, southern Iran, during 2005.Results: IGF-1 levels were significantly lower in b-thalassemia minor children than normal children (P = 0.015). This result demonstrates that some etiologies of growth failure in b-thalassemia major other than those described to date can exist, which may be shared with b-thalassemia minor in feature or may be transformed by genes that are either expressed or not.Conclusion: We conclude that in addition to that observed in b-thalassemia major, IGF-1 level is also decreased in b-thalassemia minor, and these two may have similar etiologies. |
| first_indexed | 2024-04-10T13:28:55Z |
| format | Article |
| id | doaj.art-31d8e65f4d0040508f228ba9d7af367e |
| institution | Directory Open Access Journal |
| issn | 1300-7777 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T13:28:55Z |
| publishDate | 2008-09-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-31d8e65f4d0040508f228ba9d7af367e2023-02-15T16:11:45ZengGalenos Publishing HouseTurkish Journal of Hematology1300-77771308-52632008-09-012503136139Insulin-like growth factor-1 levels in children with Beta-thalassemia minorMehran KarimiHamdollah KaramifarNargrs SobhaniObjective: Growth retardation in children with b-thalassemia major is multifactorial. Some etiologies described for this condition are hemochromatosis, disturbed growth hormone (GH) / insulin growth factor-1 (IGF-1) axis, undernutrition and hypermetabolism. It has also been proven that growth retardation is present in b-thalassemia major children despite regular transfusion and chelation. Our aim was to evaluate the level of IGF-1 in b-thalassemia minor subjects and compare it with that in healthy children. Material and Methods: Fifty children aged 6 months to 15 years with b-thalassemia minor (32 males, 18 females) and 50 age- and sex-matched normal healthy children were selected. Medical history was taken and complete physical examination was done in each case; IGF-1 level was checked in all cases. This study was done in Shiraz, southern Iran, during 2005.Results: IGF-1 levels were significantly lower in b-thalassemia minor children than normal children (P = 0.015). This result demonstrates that some etiologies of growth failure in b-thalassemia major other than those described to date can exist, which may be shared with b-thalassemia minor in feature or may be transformed by genes that are either expressed or not.Conclusion: We conclude that in addition to that observed in b-thalassemia major, IGF-1 level is also decreased in b-thalassemia minor, and these two may have similar etiologies.http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-35119Thalassemiainsulin-like growth factor-1growth retardationb-thalassemia minor. |
| spellingShingle | Mehran Karimi Hamdollah Karamifar Nargrs Sobhani Insulin-like growth factor-1 levels in children with Beta-thalassemia minor Turkish Journal of Hematology Thalassemia insulin-like growth factor-1 growth retardation b-thalassemia minor. |
| title | Insulin-like growth factor-1 levels in children with Beta-thalassemia minor |
| title_full | Insulin-like growth factor-1 levels in children with Beta-thalassemia minor |
| title_fullStr | Insulin-like growth factor-1 levels in children with Beta-thalassemia minor |
| title_full_unstemmed | Insulin-like growth factor-1 levels in children with Beta-thalassemia minor |
| title_short | Insulin-like growth factor-1 levels in children with Beta-thalassemia minor |
| title_sort | insulin like growth factor 1 levels in children with beta thalassemia minor |
| topic | Thalassemia insulin-like growth factor-1 growth retardation b-thalassemia minor. |
| url | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-35119 |
| work_keys_str_mv | AT mehrankarimi insulinlikegrowthfactor1levelsinchildrenwithbetathalassemiaminor AT hamdollahkaramifar insulinlikegrowthfactor1levelsinchildrenwithbetathalassemiaminor AT nargrssobhani insulinlikegrowthfactor1levelsinchildrenwithbetathalassemiaminor |