High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis
The aim of this study was to determine the association between high-density mineralized protrusions (HDMPs) and central osteophytes (COs), and describe the varying appearance of these lesions using advanced clinical imaging and a novel histological protocol. Seventeen consecutive patients with clini...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/12/1051 |
| _version_ | 1827700669051568128 |
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| author | Alecio F. Lombardi Qingbo Tang Jonathan H. Wong Judith L. Williams Saeed Jerban Yajun Ma Hyungseok Jang Jiang Du Eric Y. Chang |
| author_facet | Alecio F. Lombardi Qingbo Tang Jonathan H. Wong Judith L. Williams Saeed Jerban Yajun Ma Hyungseok Jang Jiang Du Eric Y. Chang |
| author_sort | Alecio F. Lombardi |
| collection | DOAJ |
| description | The aim of this study was to determine the association between high-density mineralized protrusions (HDMPs) and central osteophytes (COs), and describe the varying appearance of these lesions using advanced clinical imaging and a novel histological protocol. Seventeen consecutive patients with clinically advanced knee osteoarthritis undergoing knee arthroplasty were included. Surgical tissues containing the osteochondral region were investigated using computed tomography (CT); a subset was evaluated using confocal microscopy with fluorescence. Tissues from seven subjects (41.2%) contained HDMPs, and tissues from seven subjects (41.2%) contained COs. A significant association between HDMPs and COs was present (<i>p</i> = 0.003), with 6 subjects (35.2%) demonstrating both lesions. In total, 30 HDMPs were found, most commonly at the posterior medial femoral condyle (13/30, 43%), and 19 COs were found, most commonly at the trochlea (5/19, 26.3%). The HDMPs had high vascularity at their bases in cartilaginous areas (14/20, 70%), while the surrounding areas had elevated levels of long vascular channels penetrating beyond the zone of calcified cartilage (<i>p</i> = 0.012) compared to HDMP-free areas. Both COs and HDMPs had noticeable bone-resorbing osteoclasts amassing at the osteochondral junction and in vascular channels entering cartilage. In conclusion, HDMPs and COs are associated lesions in patients with advanced knee osteoarthritis, sharing similar histologic features, including increased vascularization and metabolic bone activity at the osteochondral junction. Future studies are needed to determine the relationship of these lesions with osteoarthritis progression and symptomatology. |
| first_indexed | 2024-03-10T14:17:14Z |
| format | Article |
| id | doaj.art-31d93f712b674716b771856b727c09a3 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T14:17:14Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-31d93f712b674716b771856b727c09a32023-11-20T23:38:12ZengMDPI AGDiagnostics2075-44182020-12-011012105110.3390/diagnostics10121051High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in OsteoarthritisAlecio F. Lombardi0Qingbo Tang1Jonathan H. Wong2Judith L. Williams3Saeed Jerban4Yajun Ma5Hyungseok Jang6Jiang Du7Eric Y. Chang8Research Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAResearch Service, VA San Diego Healthcare System, San Diego, CA 92161, USAThe aim of this study was to determine the association between high-density mineralized protrusions (HDMPs) and central osteophytes (COs), and describe the varying appearance of these lesions using advanced clinical imaging and a novel histological protocol. Seventeen consecutive patients with clinically advanced knee osteoarthritis undergoing knee arthroplasty were included. Surgical tissues containing the osteochondral region were investigated using computed tomography (CT); a subset was evaluated using confocal microscopy with fluorescence. Tissues from seven subjects (41.2%) contained HDMPs, and tissues from seven subjects (41.2%) contained COs. A significant association between HDMPs and COs was present (<i>p</i> = 0.003), with 6 subjects (35.2%) demonstrating both lesions. In total, 30 HDMPs were found, most commonly at the posterior medial femoral condyle (13/30, 43%), and 19 COs were found, most commonly at the trochlea (5/19, 26.3%). The HDMPs had high vascularity at their bases in cartilaginous areas (14/20, 70%), while the surrounding areas had elevated levels of long vascular channels penetrating beyond the zone of calcified cartilage (<i>p</i> = 0.012) compared to HDMP-free areas. Both COs and HDMPs had noticeable bone-resorbing osteoclasts amassing at the osteochondral junction and in vascular channels entering cartilage. In conclusion, HDMPs and COs are associated lesions in patients with advanced knee osteoarthritis, sharing similar histologic features, including increased vascularization and metabolic bone activity at the osteochondral junction. Future studies are needed to determine the relationship of these lesions with osteoarthritis progression and symptomatology.https://www.mdpi.com/2075-4418/10/12/1051HDMPcentral osteophytesosteochondral junctionosteoarthritis |
| spellingShingle | Alecio F. Lombardi Qingbo Tang Jonathan H. Wong Judith L. Williams Saeed Jerban Yajun Ma Hyungseok Jang Jiang Du Eric Y. Chang High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis Diagnostics HDMP central osteophytes osteochondral junction osteoarthritis |
| title | High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis |
| title_full | High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis |
| title_fullStr | High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis |
| title_full_unstemmed | High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis |
| title_short | High-Density Mineralized Protrusions and Central Osteophytes: Associated Osteochondral Junction Abnormalities in Osteoarthritis |
| title_sort | high density mineralized protrusions and central osteophytes associated osteochondral junction abnormalities in osteoarthritis |
| topic | HDMP central osteophytes osteochondral junction osteoarthritis |
| url | https://www.mdpi.com/2075-4418/10/12/1051 |
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