Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

Phylogenetically informative mutations in genes implicated in antibiotic resistance in Mycobacterium tuberculosis complex

Abstract Background A comprehensive understanding of the pre-existing genetic variation in genes associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is needed to accurately interpret whole-genome sequencing data for genotypic drug susceptibility testing (DST). Meth...

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Bibliographic Details
Main Authors: Matthias Merker, Thomas A. Kohl, Ivan Barilar, Sönke Andres, Philip W. Fowler, Erja Chryssanthou, Kristian Ängeby, Pontus Jureen, Danesh Moradigaravand, Julian Parkhill, Sharon J. Peacock, Thomas Schön, Florian P. Maurer, Timothy Walker, Claudio Köser, Stefan Niemann
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Genome Medicine
Subjects:
Mycobacterium tuberculosis
Drug resistance
Benign mutations
Intrinsic resistance
Online Access:http://link.springer.com/article/10.1186/s13073-020-00726-5

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