A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen
BACKGROUND AND AIM:This study aimed to solve the problems faced with the previous model of inflammatory tooth painin rats.METHODS:After cutting 2 mm of the distal extremities, the polyethylene crownswere placed on the mandibularincisors. In contrast to the original model, we used flow composite inst...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kerman University of Medical Sciences
2012-09-01
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| Series: | Journal of Oral Health and Oral Epidemiology |
| Subjects: | |
| Online Access: | http://johoe.kmu.ac.ir/index.php/johoe/article/view/14/23 |
| _version_ | 1818359892479574016 |
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| author | Maryam Raoof DDS, MS Mehdi Abbasnejad PhD Ladan Amirkhosravi MSc Hamed Ebrahimnejad DDS Ramin Raoof |
| author_facet | Maryam Raoof DDS, MS Mehdi Abbasnejad PhD Ladan Amirkhosravi MSc Hamed Ebrahimnejad DDS Ramin Raoof |
| author_sort | Maryam Raoof DDS, MS |
| collection | DOAJ |
| description | BACKGROUND AND AIM:This study aimed to solve the problems faced with the previous model of inflammatory tooth painin rats.METHODS:After cutting 2 mm of the distal extremities, the polyethylene crownswere placed on the mandibularincisors. In contrast to the original model, we used flow composite instead of wire in order to maximize the retention ofcrowns. Different concentrations of capsaicin (10, 25 and 100 mg/ml) and formalin were administrated into the cavitiesunder the crowns. The algesic agent-induced behaviors were evaluated.RESULTS:The modified model had no liquid leakage. Furthermore, composite allowed the crowns to remain for alonger period of time. Capsaicin 25, 100 mg/ml and formalin applications induced significantly more painfulstimulation compared with control groups (P < 0.001). These responses were significantly reduced by theadministration of ibuprofen, 20 minutes prior to the capsaicin 100 mg/ml injection.CONCLUSIONS:This model seems to be adequate for long-term pain related experiments in which fluid leakageelimination is important. |
| first_indexed | 2024-12-13T20:52:07Z |
| format | Article |
| id | doaj.art-31e37737c81b494fa529cc50c85d0d6e |
| institution | Directory Open Access Journal |
| issn | 2322-1372 |
| language | English |
| last_indexed | 2024-12-13T20:52:07Z |
| publishDate | 2012-09-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Oral Health and Oral Epidemiology |
| spelling | doaj.art-31e37737c81b494fa529cc50c85d0d6e2022-12-21T23:31:51ZengKerman University of Medical SciencesJournal of Oral Health and Oral Epidemiology2322-13722012-09-01127077A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofenMaryam Raoof DDS, MSMehdi Abbasnejad PhDLadan Amirkhosravi MScHamed Ebrahimnejad DDSRamin RaoofBACKGROUND AND AIM:This study aimed to solve the problems faced with the previous model of inflammatory tooth painin rats.METHODS:After cutting 2 mm of the distal extremities, the polyethylene crownswere placed on the mandibularincisors. In contrast to the original model, we used flow composite instead of wire in order to maximize the retention ofcrowns. Different concentrations of capsaicin (10, 25 and 100 mg/ml) and formalin were administrated into the cavitiesunder the crowns. The algesic agent-induced behaviors were evaluated.RESULTS:The modified model had no liquid leakage. Furthermore, composite allowed the crowns to remain for alonger period of time. Capsaicin 25, 100 mg/ml and formalin applications induced significantly more painfulstimulation compared with control groups (P < 0.001). These responses were significantly reduced by theadministration of ibuprofen, 20 minutes prior to the capsaicin 100 mg/ml injection.CONCLUSIONS:This model seems to be adequate for long-term pain related experiments in which fluid leakageelimination is important.http://johoe.kmu.ac.ir/index.php/johoe/article/view/14/23OdontalgiaCapsaicinFormalinModelRat |
| spellingShingle | Maryam Raoof DDS, MS Mehdi Abbasnejad PhD Ladan Amirkhosravi MSc Hamed Ebrahimnejad DDS Ramin Raoof A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen Journal of Oral Health and Oral Epidemiology Odontalgia Capsaicin Formalin Model Rat |
| title | A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_full | A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_fullStr | A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_full_unstemmed | A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_short | A modification of a previous model fo r inflammatory tooth pain: Effects of different capsaicin and formalin concentrations and ibuprofen |
| title_sort | modification of a previous model fo r inflammatory tooth pain effects of different capsaicin and formalin concentrations and ibuprofen |
| topic | Odontalgia Capsaicin Formalin Model Rat |
| url | http://johoe.kmu.ac.ir/index.php/johoe/article/view/14/23 |
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