The marine natural product mimic MPM-1 is cytolytic and induces DAMP release from human cancer cell lines
Abstract Bioprospecting contributes to the discovery of new molecules with anticancer properties. Compounds with cytolytic activity and the ability to induce immunogenic cell death can be administered as intratumoral injections with the aim to activate anti-tumor immune responses by causing the rele...
Main Authors: | Susannah von Hofsten, Marianne Hagensen Paulsen, Synnøve Norvoll Magnussen, Dominik Ausbacher, Mathias Kranz, Annette Bayer, Morten B. Strøm, Gerd Berge |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-09-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-19597-4 |
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