Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report
Metastatic spread to the salivary glands is rare, occurring primarily from head and neck tumors to the parotid gland. So far, only one sublingual gland metastasis has been reported in the literature. We herein report the second case of metastasis to this gland occurring in a woman in her 50s, prev...
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| Format: | Article |
| Language: | English |
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Sociedade Portuguesa de Estomatologia e Medicina Dentária
2023-03-01
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| Series: | Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial |
| Subjects: | |
| Online Access: | http://administracao.spemd.pt/app/assets/imagens/files_img/1_19_642abbc38eb0f.pdf |
| _version_ | 1797847549795631104 |
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| author | Vânia Almeida Carlos Salgado Pedro Ferraz Lina Carvalho |
| author_facet | Vânia Almeida Carlos Salgado Pedro Ferraz Lina Carvalho |
| author_sort | Vânia Almeida |
| collection | DOAJ |
| description | Metastatic spread to the salivary glands is rare, occurring primarily from head and neck
tumors to the parotid gland. So far, only one sublingual gland metastasis has been reported in the literature. We herein report the second case of metastasis to this gland
occurring in a woman in her 50s, previously diagnosed with HER2-positive metaplastic
breast carcinoma (MpBC) with chondroid differentiation, with lymph node and diffuse
organ metastases. The sublingual lesion presented as a tumefaction on the floor of the
mouth, causing masticatory discomfort. Histologically it was formed by epithelial cells
with high-grade cytomorphological features with a large central area of chondroid differentiation. The case was clinically and pathologically challenging, given the rarity of
the primary MpBC and the improbable secondary location. Alternative primary salivary
gland tumors with chondroid differentiation were considered, but ultimately the clinical
integration was crucial in establishing the diagnosis of MpBC metastasis to the sublingual gland. |
| first_indexed | 2024-04-09T18:13:14Z |
| format | Article |
| id | doaj.art-31e45d1909de4489b1460834268ce083 |
| institution | Directory Open Access Journal |
| issn | 1646-2890 1647-6700 |
| language | English |
| last_indexed | 2024-04-09T18:13:14Z |
| publishDate | 2023-03-01 |
| publisher | Sociedade Portuguesa de Estomatologia e Medicina Dentária |
| record_format | Article |
| series | Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial |
| spelling | doaj.art-31e45d1909de4489b1460834268ce0832023-04-13T10:11:02ZengSociedade Portuguesa de Estomatologia e Medicina DentáriaRevista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial1646-28901647-67002023-03-01641505410.24873/j.rpemd.2023.03.1054Metastasis to the sublingual gland of metaplastic breast carcinoma – a case reportVânia Almeida0https://orcid.org/0000-0002-2202-7402Carlos Salgado1https://orcid.org/0000-0002-8243-4413Pedro Ferraz2https://orcid.org/0000-0003-0753-1608Lina Carvalho3https://orcid.org/0000-0001-8349-4488Centro Hospitalar e Universitário de Coimbra – Serviço de Anatomia Patológica, Coimbra, Portugal; Faculdade de Medicina da Universidade de Coimbra, Coimbra, PortugalCentro Hospitalar e Universitário de Coimbra – Serviço de Estomatologia, Coimbra, PortugalCentro Hospitalar e Universitário de Coimbra – Serviço de Estomatologia, Coimbra, PortugalCentro Hospitalar e Universitário de Coimbra – Serviço de Anatomia Patológica, Coimbra, Portugal; Faculdade de Medicina da Universidade de Coimbra, Coimbra, PortugalMetastatic spread to the salivary glands is rare, occurring primarily from head and neck tumors to the parotid gland. So far, only one sublingual gland metastasis has been reported in the literature. We herein report the second case of metastasis to this gland occurring in a woman in her 50s, previously diagnosed with HER2-positive metaplastic breast carcinoma (MpBC) with chondroid differentiation, with lymph node and diffuse organ metastases. The sublingual lesion presented as a tumefaction on the floor of the mouth, causing masticatory discomfort. Histologically it was formed by epithelial cells with high-grade cytomorphological features with a large central area of chondroid differentiation. The case was clinically and pathologically challenging, given the rarity of the primary MpBC and the improbable secondary location. Alternative primary salivary gland tumors with chondroid differentiation were considered, but ultimately the clinical integration was crucial in establishing the diagnosis of MpBC metastasis to the sublingual gland. http://administracao.spemd.pt/app/assets/imagens/files_img/1_19_642abbc38eb0f.pdfbreast carcinomametastasissublingual gland |
| spellingShingle | Vânia Almeida Carlos Salgado Pedro Ferraz Lina Carvalho Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial breast carcinoma metastasis sublingual gland |
| title | Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report |
| title_full | Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report |
| title_fullStr | Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report |
| title_full_unstemmed | Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report |
| title_short | Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report |
| title_sort | metastasis to the sublingual gland of metaplastic breast carcinoma a case report |
| topic | breast carcinoma metastasis sublingual gland |
| url | http://administracao.spemd.pt/app/assets/imagens/files_img/1_19_642abbc38eb0f.pdf |
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