Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies
The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from <i>Cannabis sativa</i>, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for pharmacologi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/2/155 |
| _version_ | 1797618799778725888 |
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| author | Mariana Luz-Veiga João Azevedo-Silva João C. Fernandes |
| author_facet | Mariana Luz-Veiga João Azevedo-Silva João C. Fernandes |
| author_sort | Mariana Luz-Veiga |
| collection | DOAJ |
| description | The phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from <i>Cannabis sativa</i>, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for pharmacological uses due to its anti-inflammatory, antioxidant, anticonvulsant, and anxiolytic potential. The molecular mechanisms involved in CBD’s biological effects are not limited to its interaction with classical cannabinoid receptors, exerting anti-inflammatory or pain-relief effects. Several pieces of evidence demonstrate that CBD interacts with other receptors and cellular signaling cascades, which further support CBD’s therapeutic potential beyond pain management. In this review, we take a closer look at the molecular mechanisms of CBD and its potential therapeutic application in the context of cancer, neurodegeneration, and autoimmune diseases. |
| first_indexed | 2024-03-11T08:17:41Z |
| format | Article |
| id | doaj.art-31e5e653f5ef4761bff05fe44e2baa1a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T08:17:41Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-31e5e653f5ef4761bff05fe44e2baa1a2023-11-16T22:35:47ZengMDPI AGPharmaceuticals1424-82472023-01-0116215510.3390/ph16020155Beyond Pain Relief: A Review on Cannabidiol Potential in Medical TherapiesMariana Luz-Veiga0João Azevedo-Silva1João C. Fernandes2CBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, 4169-005 Porto, PortugalCBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, 4169-005 Porto, PortugalCBQF—Centro de Biotecnologia e Química Fina—Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, 4169-005 Porto, PortugalThe phytocannabinoid cannabidiol (CBD) is receiving increasing attention due to its pharmacological properties. Although CBD is extracted from <i>Cannabis sativa</i>, it lacks the psychoactive effects of Δ9-tetrahydrocannabinol (THC) and has become an attractive compound for pharmacological uses due to its anti-inflammatory, antioxidant, anticonvulsant, and anxiolytic potential. The molecular mechanisms involved in CBD’s biological effects are not limited to its interaction with classical cannabinoid receptors, exerting anti-inflammatory or pain-relief effects. Several pieces of evidence demonstrate that CBD interacts with other receptors and cellular signaling cascades, which further support CBD’s therapeutic potential beyond pain management. In this review, we take a closer look at the molecular mechanisms of CBD and its potential therapeutic application in the context of cancer, neurodegeneration, and autoimmune diseases.https://www.mdpi.com/1424-8247/16/2/155cannabidiolcannabinoidscancerneurologic conditionsauto immune diseases |
| spellingShingle | Mariana Luz-Veiga João Azevedo-Silva João C. Fernandes Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies Pharmaceuticals cannabidiol cannabinoids cancer neurologic conditions auto immune diseases |
| title | Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies |
| title_full | Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies |
| title_fullStr | Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies |
| title_full_unstemmed | Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies |
| title_short | Beyond Pain Relief: A Review on Cannabidiol Potential in Medical Therapies |
| title_sort | beyond pain relief a review on cannabidiol potential in medical therapies |
| topic | cannabidiol cannabinoids cancer neurologic conditions auto immune diseases |
| url | https://www.mdpi.com/1424-8247/16/2/155 |
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