Robust dimethyl‐based multiplex‐DIA doubles single‐cell proteome depth via a reference channel

Robust dimethyl‐based multiplex‐DIA doubles single‐cell proteome depth via a reference channel

Abstract Single‐cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput, and robustness, which we address here by a streamlined multiplexed workflow using data‐independent acquis...

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Bibliographic Details
Main Authors: Marvin Thielert, Ericka CM Itang, Constantin Ammar, Florian A Rosenberger, Isabell Bludau, Lisa Schweizer, Thierry M Nordmann, Patricia Skowronek, Maria Wahle, Wen‐Feng Zeng, Xie‐Xuan Zhou, Andreas‐David Brunner, Sabrina Richter, Mitchell P Levesque, Fabian J Theis, Martin Steger, Matthias Mann
Format: Article
Language:English
Published: Springer Nature 2023-09-01
Series:Molecular Systems Biology
Subjects:
DIA
dimethyl labeling
multiplexing
single cells
spatial proteomics
Online Access:https://doi.org/10.15252/msb.202211503

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