Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice

Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice

Deletion of the nuclear hormone receptor small heterodimer partner (Shp) ameliorates the development of obesity and nonalcoholic steatohepatitis (NASH) in mice. Liver-specific SHP plays a significant role in this amelioration. The gut microbiota has been associated with these metabolic disorders, an...

Full description

Bibliographic Details
Main Authors: Ryan Mifflin, Jung Eun Park, Mikang Lee, Prasant Kumar Jena, Yu-Jui Yvonne Wan, Hazel A. Barton, Mirjavid Aghayev, Takhar Kasumov, Li Lin, Xinwen Wang, Robert Novak, Feng Li, He Huang, Leah P. Shriver, Yoon-Kwang Lee
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Lipid Research
Subjects:
bile acids and salts
inflammation
intestine
liver
nuclear receptor/RXR
PPARs
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227523001426

Internet

http://www.sciencedirect.com/science/article/pii/S0022227523001426

Similar Items