The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury
<i>Background and Objectives</i>: This study was conducted to examine the influence of different swimming and running protocols as forms of physiological preconditioning on an isolated rat heart’s ischemia/reperfusion injury. <i>Materials and Methods</i>: This study was condu...
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2023-11-01
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| Online Access: | https://www.mdpi.com/1648-9144/59/11/1995 |
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| author | Milos Glisic Tamara Nikolic Turnic Vladimir Zivkovic Bozidar Pindovic Natalia Vasilievna Chichkova Vladimir Petrovich Fisenko Marina Nikolic Lazar Stijak Lemina Elena Yurievna Mirjana Veselinovic Milena Jovicic Katarina Mihajlovic Sergey Bolevich Vladimir Jakovljevic |
| author_facet | Milos Glisic Tamara Nikolic Turnic Vladimir Zivkovic Bozidar Pindovic Natalia Vasilievna Chichkova Vladimir Petrovich Fisenko Marina Nikolic Lazar Stijak Lemina Elena Yurievna Mirjana Veselinovic Milena Jovicic Katarina Mihajlovic Sergey Bolevich Vladimir Jakovljevic |
| author_sort | Milos Glisic |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: This study was conducted to examine the influence of different swimming and running protocols as forms of physiological preconditioning on an isolated rat heart’s ischemia/reperfusion injury. <i>Materials and Methods</i>: This study was conducted on 60 male Wistar albino rats (6 weeks old, bw: 200 ± 20 g), divided into: CTRL group—a sedentary control group; sAeT—a group that underwent aerobic swimming conditioning using a swimming protocol for 8 weeks; sAnT—a group that underwent anaerobic swimming conditioning; rAeT—a group that underwent aerobic running conditioning; and rAnT—a group that underwent anaerobic running conditioning. After the preconditioning protocols, ex vivo estimating of myocardial function according to the Langendorff technique was performed. <i>Results</i>: The anaerobic running training decreased heart rate and the anaerobic swimming training reduced coronary flow, demonstrating the difference in the physiological heart response of aerobic/anaerobic physical training (<i>p</i> < 0.05). Heart rate was significantly reduced in both training swimming groups after a period of ischemia (<i>p</i> < 0.05). On the other hand, the anaerobic running protocol induced a significantly decreased heart rate in comparison with the aerobic running group and the sedentary group (<i>p</i> < 0.05). <i>Conclusions</i>: The data from this experimental study support many protective training effects, i.e., improved contractility, improved resting heart rate, and increased physical work capacity and exercise tolerance. Physical training in the form of anaerobic running induces greater heart preconditioning for reperfusion injury in comparison with anaerobic swimming training. |
| first_indexed | 2024-03-09T16:37:58Z |
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| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-09T16:37:58Z |
| publishDate | 2023-11-01 |
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| series | Medicina |
| spelling | doaj.art-31eb0602050646f787e30858a5c1bd7e2023-11-24T14:54:57ZengMDPI AGMedicina1010-660X1648-91442023-11-015911199510.3390/medicina59111995The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion InjuryMilos Glisic0Tamara Nikolic Turnic1Vladimir Zivkovic2Bozidar Pindovic3Natalia Vasilievna Chichkova4Vladimir Petrovich Fisenko5Marina Nikolic6Lazar Stijak7Lemina Elena Yurievna8Mirjana Veselinovic9Milena Jovicic10Katarina Mihajlovic11Sergey Bolevich12Vladimir Jakovljevic13Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment Faculty Therapy, University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, RussiaDepartment of Pharmacology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, RussiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaInstitute of Anatomy, School of Medicine University in Belgrade, Dr Subotica 4/II., 11000 Belgrade, Serbia1st Moscow State Medical, University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, RussiaDepartment of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Communication Skills, Faculty of Medical Sciences, University of Kragujevac, 34000 Kragujevac, SerbiaDepartment of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, SerbiaDepartment of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya Street 8, Str. 2, 119991 Moscow, RussiaDepartment of Physiology, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovica 69, 34000 Kragujevac, Serbia<i>Background and Objectives</i>: This study was conducted to examine the influence of different swimming and running protocols as forms of physiological preconditioning on an isolated rat heart’s ischemia/reperfusion injury. <i>Materials and Methods</i>: This study was conducted on 60 male Wistar albino rats (6 weeks old, bw: 200 ± 20 g), divided into: CTRL group—a sedentary control group; sAeT—a group that underwent aerobic swimming conditioning using a swimming protocol for 8 weeks; sAnT—a group that underwent anaerobic swimming conditioning; rAeT—a group that underwent aerobic running conditioning; and rAnT—a group that underwent anaerobic running conditioning. After the preconditioning protocols, ex vivo estimating of myocardial function according to the Langendorff technique was performed. <i>Results</i>: The anaerobic running training decreased heart rate and the anaerobic swimming training reduced coronary flow, demonstrating the difference in the physiological heart response of aerobic/anaerobic physical training (<i>p</i> < 0.05). Heart rate was significantly reduced in both training swimming groups after a period of ischemia (<i>p</i> < 0.05). On the other hand, the anaerobic running protocol induced a significantly decreased heart rate in comparison with the aerobic running group and the sedentary group (<i>p</i> < 0.05). <i>Conclusions</i>: The data from this experimental study support many protective training effects, i.e., improved contractility, improved resting heart rate, and increased physical work capacity and exercise tolerance. Physical training in the form of anaerobic running induces greater heart preconditioning for reperfusion injury in comparison with anaerobic swimming training.https://www.mdpi.com/1648-9144/59/11/1995aerobic preconditioninganaerobic performanceswimmingrunningratmyocardial ischemia |
| spellingShingle | Milos Glisic Tamara Nikolic Turnic Vladimir Zivkovic Bozidar Pindovic Natalia Vasilievna Chichkova Vladimir Petrovich Fisenko Marina Nikolic Lazar Stijak Lemina Elena Yurievna Mirjana Veselinovic Milena Jovicic Katarina Mihajlovic Sergey Bolevich Vladimir Jakovljevic The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury Medicina aerobic preconditioning anaerobic performance swimming running rat myocardial ischemia |
| title | The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury |
| title_full | The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury |
| title_fullStr | The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury |
| title_full_unstemmed | The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury |
| title_short | The Enhanced Effects of Swimming and Running Preconditioning in an Experimental Model of Myocardial Ischemia/Reperfusion Injury |
| title_sort | enhanced effects of swimming and running preconditioning in an experimental model of myocardial ischemia reperfusion injury |
| topic | aerobic preconditioning anaerobic performance swimming running rat myocardial ischemia |
| url | https://www.mdpi.com/1648-9144/59/11/1995 |
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