Experimental Models for Studying Food AllergySummary
Immunoglobulin E–mediated food allergy is rapidly developing into a global health problem. Publicly available therapeutic intervention strategies are currently restricted to allergen avoidance and emergency treatments. To gain a better understanding of the disease pathophysiology so that new therapi...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X18300869 |
| _version_ | 1811324789836480512 |
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| author | Cynthia Kanagaratham Benjamin F. Sallis Edda Fiebiger |
| author_facet | Cynthia Kanagaratham Benjamin F. Sallis Edda Fiebiger |
| author_sort | Cynthia Kanagaratham |
| collection | DOAJ |
| description | Immunoglobulin E–mediated food allergy is rapidly developing into a global health problem. Publicly available therapeutic intervention strategies are currently restricted to allergen avoidance and emergency treatments. To gain a better understanding of the disease pathophysiology so that new therapies can be developed, major research efforts have been put into studying food allergy in mice. Animal models should reflect the human pathology as closely as possible to allow for a rapid translation of basic science observations to the bedside. In this regard, experimental models of food allergy provide significant challenges for research because of discrepancies between the presentation of disease in humans and mice. The goal of this review is to give a summary of commonly used murine disease models and to discuss how they relate to the human condition. We will focus on epicutaneous sensitization models, on mouse strains that sensitize spontaneously to food as seen in humans, and on models in humanized animals. In summary, expanding the research toolbox of experimental food allergy provides an important step toward closing gaps in our understanding of the derailing immune mechanism that underlies the human disease. The availability of additional experimental models will provide exciting opportunities to discover new intervention points for the treatment of food allergies. (Cell Mol Gastroenterol Hepatol 2018;x:x) Keywords: Murine Models of Food Allergy, Epictutaneous Sensitization, Spontaneous Sensitization, Humanized Model, FCERIA, IgE, Anaphylaxis, Allergen Sensitization, Allergen Challenge |
| first_indexed | 2024-04-13T14:21:38Z |
| format | Article |
| id | doaj.art-31ed969983ec45edbd3eebaf4fa96cc5 |
| institution | Directory Open Access Journal |
| issn | 2352-345X |
| language | English |
| last_indexed | 2024-04-13T14:21:38Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj.art-31ed969983ec45edbd3eebaf4fa96cc52022-12-22T02:43:26ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2018-01-0163356369.e1Experimental Models for Studying Food AllergySummaryCynthia Kanagaratham0Benjamin F. Sallis1Edda Fiebiger2Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MassachusettsDivision of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MassachusettsCorrespondence Address correspondence to: Edda Fiebiger, PhD, 300 Longwood Avenue, EN630, Boston, Massachusetts 02115. fax: (617) 730-0498.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MassachusettsImmunoglobulin E–mediated food allergy is rapidly developing into a global health problem. Publicly available therapeutic intervention strategies are currently restricted to allergen avoidance and emergency treatments. To gain a better understanding of the disease pathophysiology so that new therapies can be developed, major research efforts have been put into studying food allergy in mice. Animal models should reflect the human pathology as closely as possible to allow for a rapid translation of basic science observations to the bedside. In this regard, experimental models of food allergy provide significant challenges for research because of discrepancies between the presentation of disease in humans and mice. The goal of this review is to give a summary of commonly used murine disease models and to discuss how they relate to the human condition. We will focus on epicutaneous sensitization models, on mouse strains that sensitize spontaneously to food as seen in humans, and on models in humanized animals. In summary, expanding the research toolbox of experimental food allergy provides an important step toward closing gaps in our understanding of the derailing immune mechanism that underlies the human disease. The availability of additional experimental models will provide exciting opportunities to discover new intervention points for the treatment of food allergies. (Cell Mol Gastroenterol Hepatol 2018;x:x) Keywords: Murine Models of Food Allergy, Epictutaneous Sensitization, Spontaneous Sensitization, Humanized Model, FCERIA, IgE, Anaphylaxis, Allergen Sensitization, Allergen Challengehttp://www.sciencedirect.com/science/article/pii/S2352345X18300869 |
| spellingShingle | Cynthia Kanagaratham Benjamin F. Sallis Edda Fiebiger Experimental Models for Studying Food AllergySummary Cellular and Molecular Gastroenterology and Hepatology |
| title | Experimental Models for Studying Food AllergySummary |
| title_full | Experimental Models for Studying Food AllergySummary |
| title_fullStr | Experimental Models for Studying Food AllergySummary |
| title_full_unstemmed | Experimental Models for Studying Food AllergySummary |
| title_short | Experimental Models for Studying Food AllergySummary |
| title_sort | experimental models for studying food allergysummary |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X18300869 |
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