The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study
Alpha-fetoprotein (AFP)-producing adenocarcinoma from the gastrointestinal tract (APA-GI) is a rare type of highly malignant tumor with a poor prognosis. It may originate from any site along the GI tract with similar clinicopathological characteristics. As limited research had ever described the cha...
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| Format: | Article |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.635537/full |
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| author | Xiang-Xing Kong Xiang-Xing Kong Xin-Lin Li Xin-Lin Li Xin-Lin Li Yu Tian Qian-Cheng Ye Xiao-Ming Xu Xiao-Ming Xu Yue Liu Yue Liu Qi Yang Qi Yang Li-Na Zhang Li-Na Zhang Yan-Xia Mei Yan-Xia Mei Ji-Hang Wen Ji-Hang Wen Qian Xiao Qian Xiao Jing-Song Li Jing-Song Li Ke-Feng Ding Ke-Feng Ding Jun Li Jun Li |
| author_facet | Xiang-Xing Kong Xiang-Xing Kong Xin-Lin Li Xin-Lin Li Xin-Lin Li Yu Tian Qian-Cheng Ye Xiao-Ming Xu Xiao-Ming Xu Yue Liu Yue Liu Qi Yang Qi Yang Li-Na Zhang Li-Na Zhang Yan-Xia Mei Yan-Xia Mei Ji-Hang Wen Ji-Hang Wen Qian Xiao Qian Xiao Jing-Song Li Jing-Song Li Ke-Feng Ding Ke-Feng Ding Jun Li Jun Li |
| author_sort | Xiang-Xing Kong |
| collection | DOAJ |
| description | Alpha-fetoprotein (AFP)-producing adenocarcinoma from the gastrointestinal tract (APA-GI) is a rare type of highly malignant tumor with a poor prognosis. It may originate from any site along the GI tract with similar clinicopathological characteristics. As limited research had ever described the characteristics of APA-GI, the present article intends to systemically investigate the clinicopathological characteristics of APA-GI from a single center's retrospective study to deepen the understanding of the disease. A total of 177 patients pathologically diagnosed with APA-GI between 2010 and 2017 at the Second Affiliated Hospital of Zhejiang University, School of Medicine, were included. Also, clinical data of 419 gastric cancers and 609 colorectal cancers from The Cancer Genome Atlas database were also extracted. Clinical information of patients from Second Affiliated Hospital of Zhejiang University, School of Medicine, was collected, and a median follow-up of 14.5 months was performed to investigate clinical characteristics of APA-GI. For the pathological characteristics of APA-GI, hematoxylin–eosin sections were reviewed, and immunohistochemistry of AFP was performed. The results showed that the primary tumor could develop through the whole GI tract, including the esophagus (0.6%), stomach (83.1%), duodenum (1.1%), ileum (0.6%), appendix (0.6%), colon (5.1%), and rectum (7.9%). Hepatoid adenocarcinoma is the main pathological feature of APA-GI. AFP expression level in tumor tissue was not strictly associated with serum AFP or hepatoid differentiation. The prognosis of APA-GI was worse than that of common adenocarcinoma of the GI tract and liver metastasis, and high AFP levels suggest poor prognosis in patients with APA-GI. Therefore, the present study was the first research to systemically explore the clinicopathological characteristics of APA-GI. APA-GI occurs through the whole GI tract with a significantly worse prognosis than common adenocarcinoma of GI. APA-GI should be regarded as one kind of disease for its similar clinicopathological characteristics within patients. |
| first_indexed | 2024-12-17T01:09:52Z |
| format | Article |
| id | doaj.art-31ee427e378b49a29193cc58d9a97be4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T01:09:52Z |
| publishDate | 2021-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-31ee427e378b49a29193cc58d9a97be42022-12-21T22:09:10ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-04-011110.3389/fonc.2021.635537635537The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective StudyXiang-Xing Kong0Xiang-Xing Kong1Xin-Lin Li2Xin-Lin Li3Xin-Lin Li4Yu Tian5Qian-Cheng Ye6Xiao-Ming Xu7Xiao-Ming Xu8Yue Liu9Yue Liu10Qi Yang11Qi Yang12Li-Na Zhang13Li-Na Zhang14Yan-Xia Mei15Yan-Xia Mei16Ji-Hang Wen17Ji-Hang Wen18Qian Xiao19Qian Xiao20Jing-Song Li21Jing-Song Li22Ke-Feng Ding23Ke-Feng Ding24Jun Li25Jun Li26Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Breast Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, ChinaEngineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaEngineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Pathology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Pathology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaEngineering Research Center of EMR and Intelligent Expert System, Ministry of Education, College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, ChinaResearch Center for Healthcare Data Science, Zhejiang Lab, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaDepartment of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaZhejiang University Cancer Center, Hangzhou, ChinaAlpha-fetoprotein (AFP)-producing adenocarcinoma from the gastrointestinal tract (APA-GI) is a rare type of highly malignant tumor with a poor prognosis. It may originate from any site along the GI tract with similar clinicopathological characteristics. As limited research had ever described the characteristics of APA-GI, the present article intends to systemically investigate the clinicopathological characteristics of APA-GI from a single center's retrospective study to deepen the understanding of the disease. A total of 177 patients pathologically diagnosed with APA-GI between 2010 and 2017 at the Second Affiliated Hospital of Zhejiang University, School of Medicine, were included. Also, clinical data of 419 gastric cancers and 609 colorectal cancers from The Cancer Genome Atlas database were also extracted. Clinical information of patients from Second Affiliated Hospital of Zhejiang University, School of Medicine, was collected, and a median follow-up of 14.5 months was performed to investigate clinical characteristics of APA-GI. For the pathological characteristics of APA-GI, hematoxylin–eosin sections were reviewed, and immunohistochemistry of AFP was performed. The results showed that the primary tumor could develop through the whole GI tract, including the esophagus (0.6%), stomach (83.1%), duodenum (1.1%), ileum (0.6%), appendix (0.6%), colon (5.1%), and rectum (7.9%). Hepatoid adenocarcinoma is the main pathological feature of APA-GI. AFP expression level in tumor tissue was not strictly associated with serum AFP or hepatoid differentiation. The prognosis of APA-GI was worse than that of common adenocarcinoma of the GI tract and liver metastasis, and high AFP levels suggest poor prognosis in patients with APA-GI. Therefore, the present study was the first research to systemically explore the clinicopathological characteristics of APA-GI. APA-GI occurs through the whole GI tract with a significantly worse prognosis than common adenocarcinoma of GI. APA-GI should be regarded as one kind of disease for its similar clinicopathological characteristics within patients.https://www.frontiersin.org/articles/10.3389/fonc.2021.635537/fullAFP-producinggastrointestinaladenocarcinomaclinical characteristicpathological characteristic |
| spellingShingle | Xiang-Xing Kong Xiang-Xing Kong Xin-Lin Li Xin-Lin Li Xin-Lin Li Yu Tian Qian-Cheng Ye Xiao-Ming Xu Xiao-Ming Xu Yue Liu Yue Liu Qi Yang Qi Yang Li-Na Zhang Li-Na Zhang Yan-Xia Mei Yan-Xia Mei Ji-Hang Wen Ji-Hang Wen Qian Xiao Qian Xiao Jing-Song Li Jing-Song Li Ke-Feng Ding Ke-Feng Ding Jun Li Jun Li The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study Frontiers in Oncology AFP-producing gastrointestinal adenocarcinoma clinical characteristic pathological characteristic |
| title | The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study |
| title_full | The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study |
| title_fullStr | The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study |
| title_full_unstemmed | The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study |
| title_short | The Clinicopathological Characteristics of Alpha-Fetoprotein-Producing Adenocarcinoma of the Gastrointestinal Tract—A Single-Center Retrospective Study |
| title_sort | clinicopathological characteristics of alpha fetoprotein producing adenocarcinoma of the gastrointestinal tract a single center retrospective study |
| topic | AFP-producing gastrointestinal adenocarcinoma clinical characteristic pathological characteristic |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.635537/full |
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