Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice

Pyrroloquinoline quinone inhibits PCSK9-NLRP3 mediated pyroptosis of Leydig cells in obese mice

Abstract Abnormal lipid metabolism and chronic low-grade inflammation are the main traits of obesity. Especially, the molecular mechanism of concomitant deficiency in steroidogenesis-associated enzymes related to testosterone (T) synthesis of obesity dominated a decline in male fertility is still po...

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Bibliographic Details
Main Authors:	Jinyuan Wang, Shun Zhang, Linlin Hu, Yan Wang, Ke Liu, Jianghua Le, Yongpeng Tan, Tianlong Li, Haoxuan Xue, Yanhong Wei, Ou Zhong, Junhui He, Dan Zi, Xin Lei, Renhe Deng, Yafei Luo, Masong Tang, Mingxuan Su, Yichang Cao, Qingyou Liu, Zhihan Tang, Xiaocan Lei
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-11-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-023-06162-8

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