Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype

Branched‐Chain Amino Acid Accumulation Fuels the Senescence‐Associated Secretory Phenotype

Abstract The essential branched‐chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs’ full effects on mammalian physiology remain uncertain due to the complexities of B...

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Bibliographic Details
Main Authors: Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B. Alexander, Qi‐Jing Li, Tso‐Pang Yao, Zhao Zhang, Xiao‐Fan Wang
Format: Article
Language:English
Published: Wiley 2024-01-01
Series:Advanced Science
Subjects:
age‐related inflammation
BCAA
mTORC1
SASP
senescence
Online Access:https://doi.org/10.1002/advs.202303489

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