Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease
Background A parental history of cardiovascular disease (CVD) confers greater risk of future CVD among offspring. Whether the presence of parental modifiable risk factors contribute to or modify CVD risk in offspring is unclear. Methods and Results We studied 6278 parent–child trios in the multigene...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-03-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027881 |
| _version_ | 1797866348984926208 |
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| author | Christy N. Taylor Dongyu Wang Martin G. Larson Emily S. Lau Emelia J. Benjamin Ralph B. D'Agostino Ramachandran S. Vasan Daniel Levy Susan Cheng Jennifer E. Ho |
| author_facet | Christy N. Taylor Dongyu Wang Martin G. Larson Emily S. Lau Emelia J. Benjamin Ralph B. D'Agostino Ramachandran S. Vasan Daniel Levy Susan Cheng Jennifer E. Ho |
| author_sort | Christy N. Taylor |
| collection | DOAJ |
| description | Background A parental history of cardiovascular disease (CVD) confers greater risk of future CVD among offspring. Whether the presence of parental modifiable risk factors contribute to or modify CVD risk in offspring is unclear. Methods and Results We studied 6278 parent–child trios in the multigenerational longitudinal Framingham Heart Study. We assessed parental history of CVD and modifiable risk factors (smoking, hypertension, diabetes, obesity, and hyperlipidemia). Multivariable Cox models were used to evaluate the association of parental history and future CVD among offspring. Among 6278 individuals (mean age 45±11 years), 44% had at least 1 parent with history of CVD. Over a median follow‐up of 15 years, 353 major CVD events occurred among offspring. Parental history of CVD conferred 1.7‐fold increased hazard of future CVD (hazard ratio [HR], 1.71 [95% CI, 1.33–2.21]). Parental obesity and smoking status were associated with higher hazard of future CVD (obesity: HR, 1.32 [95% CI, 1.06–1.64]; smoking: HR, 1.34 [95% CI, 1.07–1.68], attenuated after adjusting for offspring smoking status). By contrast, parental history of hypertension, diabetes, and hypercholesterolemia were not associated with future CVD in offspring (P>0.05 for all). Furthermore, parental risk factors did not modify the association of parental CVD history on future offspring CVD risk. Conclusions Parental history of obesity and smoking were associated with a higher hazard of future CVD in offspring. By contrast, other parental modifiable risk factors did not alter offspring CVD risk. In addition to parental CVD, the presence of parental obesity should prompt a focus on disease prevention. |
| first_indexed | 2024-04-09T23:22:44Z |
| format | Article |
| id | doaj.art-31f09a8ec0494dee92d39e1c463e656d |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-09T23:22:44Z |
| publishDate | 2023-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-31f09a8ec0494dee92d39e1c463e656d2023-03-21T11:45:26ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-03-0112610.1161/JAHA.122.027881Family History of Modifiable Risk Factors and Association With Future Cardiovascular DiseaseChristy N. Taylor0Dongyu Wang1Martin G. Larson2Emily S. Lau3Emelia J. Benjamin4Ralph B. D'Agostino5Ramachandran S. Vasan6Daniel Levy7Susan Cheng8Jennifer E. Ho9Department of Medicine Massachusetts General Hospital Boston MAHarvard Medical School Boston MADepartment of Biostatistics Boston University School of Public Health Boston MAHarvard Medical School Boston MASection of Cardiovascular Medicine, Boston Medical Center Boston University School of Medicine Boston MADepartment of Mathematics and Statistics Boston University Boston MADepartment of Epidemiology Boston University School of Public Health Boston MAThe Framingham Heart Study Framingham MADepartment of Cardiology Smidt Heart Institute, Cedars‐Sinai Medical Center Los Angeles CAHarvard Medical School Boston MABackground A parental history of cardiovascular disease (CVD) confers greater risk of future CVD among offspring. Whether the presence of parental modifiable risk factors contribute to or modify CVD risk in offspring is unclear. Methods and Results We studied 6278 parent–child trios in the multigenerational longitudinal Framingham Heart Study. We assessed parental history of CVD and modifiable risk factors (smoking, hypertension, diabetes, obesity, and hyperlipidemia). Multivariable Cox models were used to evaluate the association of parental history and future CVD among offspring. Among 6278 individuals (mean age 45±11 years), 44% had at least 1 parent with history of CVD. Over a median follow‐up of 15 years, 353 major CVD events occurred among offspring. Parental history of CVD conferred 1.7‐fold increased hazard of future CVD (hazard ratio [HR], 1.71 [95% CI, 1.33–2.21]). Parental obesity and smoking status were associated with higher hazard of future CVD (obesity: HR, 1.32 [95% CI, 1.06–1.64]; smoking: HR, 1.34 [95% CI, 1.07–1.68], attenuated after adjusting for offspring smoking status). By contrast, parental history of hypertension, diabetes, and hypercholesterolemia were not associated with future CVD in offspring (P>0.05 for all). Furthermore, parental risk factors did not modify the association of parental CVD history on future offspring CVD risk. Conclusions Parental history of obesity and smoking were associated with a higher hazard of future CVD in offspring. By contrast, other parental modifiable risk factors did not alter offspring CVD risk. In addition to parental CVD, the presence of parental obesity should prompt a focus on disease prevention.https://www.ahajournals.org/doi/10.1161/JAHA.122.027881cardiovascular diseasefamily historyFramingham |
| spellingShingle | Christy N. Taylor Dongyu Wang Martin G. Larson Emily S. Lau Emelia J. Benjamin Ralph B. D'Agostino Ramachandran S. Vasan Daniel Levy Susan Cheng Jennifer E. Ho Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular disease family history Framingham |
| title | Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease |
| title_full | Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease |
| title_fullStr | Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease |
| title_full_unstemmed | Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease |
| title_short | Family History of Modifiable Risk Factors and Association With Future Cardiovascular Disease |
| title_sort | family history of modifiable risk factors and association with future cardiovascular disease |
| topic | cardiovascular disease family history Framingham |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.027881 |
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