Trehalose as a potential therapeutic agent in different diseases
Trehalose is a natural, non-reducing disaccharide synthesized in some bacteria, fungi, plants, and insects. Due to its advantageous physical and chemical properties, trehalose can stabilize proteins and membranes, and protect cells from desiccation, heating, and freezing. Vertebrates do not synthesi...
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| Format: | Article |
| Language: | English |
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University of Belgrade, Medical Faculty
2023-01-01
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| Series: | Medicinski Podmladak |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272302030S.pdf |
| _version_ | 1797668028131835904 |
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| author | Stevanović Danijela Trajković Vladimir Vučićević Ljubica |
| author_facet | Stevanović Danijela Trajković Vladimir Vučićević Ljubica |
| author_sort | Stevanović Danijela |
| collection | DOAJ |
| description | Trehalose is a natural, non-reducing disaccharide synthesized in some bacteria, fungi, plants, and insects. Due to its advantageous physical and chemical properties, trehalose can stabilize proteins and membranes, and protect cells from desiccation, heating, and freezing. Vertebrates do not synthesize trehalose, but the beneficial effects of trehalose have been demonstrated in numerous diseases as it eliminates aggregates, misfolded proteins, and damaged organelles, and reduces hyperinflammation and oxidative stress. Trehalose induces autophagy through nuclear translocation and activation of transcription factor EB (TFEB) in an mTOR-independent manner, but increases the expression of SQSTM1/p62 and has antioxidant properties in an autophagy-independent manner. Furthermore, trehalose induces apoptosis in tumor cells by increasing membrane fluidity through the activation of caspase 3, 6 and the JNK (c-Jun N-terminal kinase) pathway. Overall, in this review, previous knowledge on the therapeutic potential of trehalose in various diseases such as dry eye syndrome, neurodegenerative diseases, and tumors, was summarized, focusing on the underlying molecular mechanisms. |
| first_indexed | 2024-03-11T20:23:06Z |
| format | Article |
| id | doaj.art-31f157545dfc489cbb9971874a9c5153 |
| institution | Directory Open Access Journal |
| issn | 0369-1527 2466-5525 |
| language | English |
| last_indexed | 2024-03-11T20:23:06Z |
| publishDate | 2023-01-01 |
| publisher | University of Belgrade, Medical Faculty |
| record_format | Article |
| series | Medicinski Podmladak |
| spelling | doaj.art-31f157545dfc489cbb9971874a9c51532023-10-02T22:17:58ZengUniversity of Belgrade, Medical FacultyMedicinski Podmladak0369-15272466-55252023-01-01742303710.5937/mp74-413780369-15272302030STrehalose as a potential therapeutic agent in different diseasesStevanović Danijela0Trajković Vladimir1Vučićević Ljubica2Univerzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Beograd, SerbiaUniverzitet u Beogradu, Medicinski fakultet, Institut za mikrobiologiju i imunologiju, Beograd, SerbiaUniverzitet u Beogradu, Institut za biološka istraživanja "Siniša Stanković", Beograd, SerbiaTrehalose is a natural, non-reducing disaccharide synthesized in some bacteria, fungi, plants, and insects. Due to its advantageous physical and chemical properties, trehalose can stabilize proteins and membranes, and protect cells from desiccation, heating, and freezing. Vertebrates do not synthesize trehalose, but the beneficial effects of trehalose have been demonstrated in numerous diseases as it eliminates aggregates, misfolded proteins, and damaged organelles, and reduces hyperinflammation and oxidative stress. Trehalose induces autophagy through nuclear translocation and activation of transcription factor EB (TFEB) in an mTOR-independent manner, but increases the expression of SQSTM1/p62 and has antioxidant properties in an autophagy-independent manner. Furthermore, trehalose induces apoptosis in tumor cells by increasing membrane fluidity through the activation of caspase 3, 6 and the JNK (c-Jun N-terminal kinase) pathway. Overall, in this review, previous knowledge on the therapeutic potential of trehalose in various diseases such as dry eye syndrome, neurodegenerative diseases, and tumors, was summarized, focusing on the underlying molecular mechanisms.https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272302030S.pdftrehaloseoxidative stressautophagytherapy |
| spellingShingle | Stevanović Danijela Trajković Vladimir Vučićević Ljubica Trehalose as a potential therapeutic agent in different diseases Medicinski Podmladak trehalose oxidative stress autophagy therapy |
| title | Trehalose as a potential therapeutic agent in different diseases |
| title_full | Trehalose as a potential therapeutic agent in different diseases |
| title_fullStr | Trehalose as a potential therapeutic agent in different diseases |
| title_full_unstemmed | Trehalose as a potential therapeutic agent in different diseases |
| title_short | Trehalose as a potential therapeutic agent in different diseases |
| title_sort | trehalose as a potential therapeutic agent in different diseases |
| topic | trehalose oxidative stress autophagy therapy |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2023/0369-15272302030S.pdf |
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