Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes
Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2006-09-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000600019 |
| _version_ | 1797703098190266368 |
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| author | Renata C Ferreira Sheila A Teles Márcia A Dias Viviane R Tavares Simonne A Silva Selma A Gomes Clara FT Yoshida Regina MB Martins |
| author_facet | Renata C Ferreira Sheila A Teles Márcia A Dias Viviane R Tavares Simonne A Silva Selma A Gomes Clara FT Yoshida Regina MB Martins |
| author_sort | Renata C Ferreira |
| collection | DOAJ |
| description | Hemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distribution. A total of 1095 patients were interviewed in 15 dialysis units. Serum samples were screened for HBV serological markers by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) positive samples were tested for HBV DNA by polymerase chain reaction and genotyped by restriction fragment length polymorphism. Global HBV infection prevalence was 29.8% (95% CI: 27.1-32.5). Multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with HBV positivity. HBV DNA was detected in 65.4% (17/26) of the HBsAg-positive samples. Thirteen of 17 HBV DNA positive samples were genotyped. Genotype D (61.5%) was predominant, followed by A (30.8%), while genotype F was detected in only one (7.7%) sample. |
| first_indexed | 2024-03-12T04:59:30Z |
| format | Article |
| id | doaj.art-31f17c5b618248279fa1567c3ee4a9d9 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T04:59:30Z |
| publishDate | 2006-09-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-31f17c5b618248279fa1567c3ee4a9d92023-09-03T09:14:10ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602006-09-01101668969210.1590/S0074-02762006000600019Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypesRenata C FerreiraSheila A TelesMárcia A DiasViviane R TavaresSimonne A SilvaSelma A GomesClara FT YoshidaRegina MB MartinsHemodialysis patients are at high risk for hepatitis B virus (HBV) infection. A survey was conducted in the hemodialysis population of the state of Goiás, Central Brazil, aiming to assess the prevalence of HBV infection, to analyse associated risk factors, and also to investigate HBV genotypes distribution. A total of 1095 patients were interviewed in 15 dialysis units. Serum samples were screened for HBV serological markers by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) positive samples were tested for HBV DNA by polymerase chain reaction and genotyped by restriction fragment length polymorphism. Global HBV infection prevalence was 29.8% (95% CI: 27.1-32.5). Multivariate analysis of risk factors showed that male gender, length of time on hemodialysis, and blood transfusion before 1993 were associated with HBV positivity. HBV DNA was detected in 65.4% (17/26) of the HBsAg-positive samples. Thirteen of 17 HBV DNA positive samples were genotyped. Genotype D (61.5%) was predominant, followed by A (30.8%), while genotype F was detected in only one (7.7%) sample.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000600019hepatitis B virushemodialysisCentral Brazil |
| spellingShingle | Renata C Ferreira Sheila A Teles Márcia A Dias Viviane R Tavares Simonne A Silva Selma A Gomes Clara FT Yoshida Regina MB Martins Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes Memorias do Instituto Oswaldo Cruz hepatitis B virus hemodialysis Central Brazil |
| title | Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes |
| title_full | Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes |
| title_fullStr | Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes |
| title_full_unstemmed | Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes |
| title_short | Hepatitis B virus infection profile in hemodialysis patients in Central Brazil: prevalence, risk factors, and genotypes |
| title_sort | hepatitis b virus infection profile in hemodialysis patients in central brazil prevalence risk factors and genotypes |
| topic | hepatitis B virus hemodialysis Central Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000600019 |
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