MV-mediated biomineralization mechanisms and treatments of biomineralized diseases
As the quality of life improves, people pay more and more attention to health. They are concerned about the causes of diseases, and seek better treatments. The most common diseases are biomineralized diseases, four different kinds of typical examples among which are selected to elaborate their mecha...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Medicine in Novel Technology and Devices |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093522000856 |
| _version_ | 1827996609398439936 |
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| author | Xuan Li Wei Zhang Yubo Fan Xufeng Niu |
| author_facet | Xuan Li Wei Zhang Yubo Fan Xufeng Niu |
| author_sort | Xuan Li |
| collection | DOAJ |
| description | As the quality of life improves, people pay more and more attention to health. They are concerned about the causes of diseases, and seek better treatments. The most common diseases are biomineralized diseases, four different kinds of typical examples among which are selected to elaborate their mechanisms and existing treatments. Whether it is tooth and bone in physiological mineralization or cartilage and blood vessel in pathological mineralization, they are all related to matrix vesicle (MV)-mediated biomineralization. MV-mediated biomineralization is the initial stage of biomineralization and the nucleation site mediating collagen mineralization. Definition, composition, biogenesis, and action mechanism of MVs are refined and expounded, especially a novel biomineralization pathway similar to exosome (EX) origin. Four differences are summarized to distinguish MVs and EXs. A series of treatments using MVs to solve biomineralized diseases such as tooth and bone defects, osteoarthritis and atherosclerosis are proposed, and the experimental extraction steps of MVs are summarized. |
| first_indexed | 2024-04-10T05:14:38Z |
| format | Article |
| id | doaj.art-31f21889d68d4df7a44eac4150e302e4 |
| institution | Directory Open Access Journal |
| issn | 2590-0935 |
| language | English |
| last_indexed | 2024-04-10T05:14:38Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj.art-31f21889d68d4df7a44eac4150e302e42023-03-09T04:13:40ZengElsevierMedicine in Novel Technology and Devices2590-09352023-03-0117100198MV-mediated biomineralization mechanisms and treatments of biomineralized diseasesXuan Li0Wei Zhang1Yubo Fan2Xufeng Niu3Key Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, ChinaTIANXINFU (Beijing) Medical Appliance Co., Ltd., Beijing, 102200, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; School of Engineering Medicine, Beihang University, Beijing, 100083, ChinaKey Laboratory of Biomechanics and Mechanobiology (Beihang University), Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Corresponding author. School of Biological Science and Medical Engineering, Beihang University, No. 37 XueYuan Road, Haidian District, Beijing, 100083, China.As the quality of life improves, people pay more and more attention to health. They are concerned about the causes of diseases, and seek better treatments. The most common diseases are biomineralized diseases, four different kinds of typical examples among which are selected to elaborate their mechanisms and existing treatments. Whether it is tooth and bone in physiological mineralization or cartilage and blood vessel in pathological mineralization, they are all related to matrix vesicle (MV)-mediated biomineralization. MV-mediated biomineralization is the initial stage of biomineralization and the nucleation site mediating collagen mineralization. Definition, composition, biogenesis, and action mechanism of MVs are refined and expounded, especially a novel biomineralization pathway similar to exosome (EX) origin. Four differences are summarized to distinguish MVs and EXs. A series of treatments using MVs to solve biomineralized diseases such as tooth and bone defects, osteoarthritis and atherosclerosis are proposed, and the experimental extraction steps of MVs are summarized.http://www.sciencedirect.com/science/article/pii/S2590093522000856Matrix vesicleBiomineralizationBiogenesisOsteoarthritisAtherosclerosis |
| spellingShingle | Xuan Li Wei Zhang Yubo Fan Xufeng Niu MV-mediated biomineralization mechanisms and treatments of biomineralized diseases Medicine in Novel Technology and Devices Matrix vesicle Biomineralization Biogenesis Osteoarthritis Atherosclerosis |
| title | MV-mediated biomineralization mechanisms and treatments of biomineralized diseases |
| title_full | MV-mediated biomineralization mechanisms and treatments of biomineralized diseases |
| title_fullStr | MV-mediated biomineralization mechanisms and treatments of biomineralized diseases |
| title_full_unstemmed | MV-mediated biomineralization mechanisms and treatments of biomineralized diseases |
| title_short | MV-mediated biomineralization mechanisms and treatments of biomineralized diseases |
| title_sort | mv mediated biomineralization mechanisms and treatments of biomineralized diseases |
| topic | Matrix vesicle Biomineralization Biogenesis Osteoarthritis Atherosclerosis |
| url | http://www.sciencedirect.com/science/article/pii/S2590093522000856 |
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