Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity
Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Proteomes |
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| Online Access: | http://www.mdpi.com/2227-7382/6/4/40 |
| _version_ | 1798035034260635648 |
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| author | Joongkyu Park |
| author_facet | Joongkyu Park |
| author_sort | Joongkyu Park |
| collection | DOAJ |
| description | Synaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity. |
| first_indexed | 2024-04-11T20:52:36Z |
| format | Article |
| id | doaj.art-31f2fae9aede40aaba9abe22a61fe7f0 |
| institution | Directory Open Access Journal |
| issn | 2227-7382 |
| language | English |
| last_indexed | 2024-04-11T20:52:36Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proteomes |
| spelling | doaj.art-31f2fae9aede40aaba9abe22a61fe7f02022-12-22T04:03:48ZengMDPI AGProteomes2227-73822018-10-01644010.3390/proteomes6040040proteomes6040040Phosphorylation of the AMPAR-TARP Complex in Synaptic PlasticityJoongkyu Park0Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USASynaptic plasticity has been considered a key mechanism underlying many brain functions including learning, memory, and drug addiction. An increase or decrease in synaptic activity of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) complex mediates the phenomena as shown in the cellular models of synaptic plasticity, long-term potentiation (LTP), and depression (LTD). In particular, protein phosphorylation shares the spotlight in expressing the synaptic plasticity. This review summarizes the studies on phosphorylation of the AMPAR pore-forming subunits and auxiliary proteins including transmembrane AMPA receptor regulatory proteins (TARPs) and discusses its role in synaptic plasticity.http://www.mdpi.com/2227-7382/6/4/40phosphorylationAMPA receptor complextransmembrane AMPA receptor regulatory proteinsynaptic plasticity |
| spellingShingle | Joongkyu Park Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity Proteomes phosphorylation AMPA receptor complex transmembrane AMPA receptor regulatory protein synaptic plasticity |
| title | Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity |
| title_full | Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity |
| title_fullStr | Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity |
| title_full_unstemmed | Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity |
| title_short | Phosphorylation of the AMPAR-TARP Complex in Synaptic Plasticity |
| title_sort | phosphorylation of the ampar tarp complex in synaptic plasticity |
| topic | phosphorylation AMPA receptor complex transmembrane AMPA receptor regulatory protein synaptic plasticity |
| url | http://www.mdpi.com/2227-7382/6/4/40 |
| work_keys_str_mv | AT joongkyupark phosphorylationoftheampartarpcomplexinsynapticplasticity |