Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinc...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-03-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/93151 |
| _version_ | 1797265101523255296 |
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| author | Houyu Zhang Yan Li Carlos F Ibáñez Meng Xie |
| author_facet | Houyu Zhang Yan Li Carlos F Ibáñez Meng Xie |
| author_sort | Houyu Zhang |
| collection | DOAJ |
| description | Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of Ucp1-&Cidea+ adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores Ucp1 expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes. |
| first_indexed | 2024-04-25T00:39:27Z |
| format | Article |
| id | doaj.art-31f30b9ec13d4d74b221cd05436b8dac |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-25T00:39:27Z |
| publishDate | 2024-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-31f30b9ec13d4d74b221cd05436b8dac2024-03-12T12:23:33ZengeLife Sciences Publications LtdeLife2050-084X2024-03-011310.7554/eLife.93151Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversionHouyu Zhang0Yan Li1Carlos F Ibáñez2Meng Xie3https://orcid.org/0000-0002-6388-9789Chinese Institute for Brain Research, Zhongguancun Life Science Park, Beijing, China; Peking University Academy for Advanced Interdisciplinary Studies, Beijing, ChinaChinese Institute for Brain Research, Zhongguancun Life Science Park, Beijing, China; Peking University Academy for Advanced Interdisciplinary Studies, Beijing, ChinaChinese Institute for Brain Research, Zhongguancun Life Science Park, Beijing, China; Peking University School of Life Sciences, Peking-Tsinghua Center for Life Sciences, Beijing, China; PKU-IDG/McGovern Institute for Brain Research, Beijing, China; Department of Neuroscience, Karolinska Institute, Stockholm, SwedenPKU-IDG/McGovern Institute for Brain Research, Beijing, China; Peking University School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Beijing, China; Department of Biosciences and Nutrition, Karolinska Institute, Flemingsberg, SwedenPerirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of Ucp1-&Cidea+ adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores Ucp1 expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes.https://elifesciences.org/articles/93151perirenal adipose tissuebrowningwhiteningsnRNA-seqcold-induciblebeige adipocyte |
| spellingShingle | Houyu Zhang Yan Li Carlos F Ibáñez Meng Xie Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion eLife perirenal adipose tissue browning whitening snRNA-seq cold-inducible beige adipocyte |
| title | Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion |
| title_full | Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion |
| title_fullStr | Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion |
| title_full_unstemmed | Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion |
| title_short | Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion |
| title_sort | perirenal adipose tissue contains a subpopulation of cold inducible adipocytes derived from brown to white conversion |
| topic | perirenal adipose tissue browning whitening snRNA-seq cold-inducible beige adipocyte |
| url | https://elifesciences.org/articles/93151 |
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