Sulforaphane Protects Against Ethanol-Induced Apoptosis in Human Neural Crest Cells Through Diminishing Ethanol-Induced Hypermethylation at the Promoters of the Genes Encoding the Inhibitor of Apoptosis Proteins

Sulforaphane Protects Against Ethanol-Induced Apoptosis in Human Neural Crest Cells Through Diminishing Ethanol-Induced Hypermethylation at the Promoters of the Genes Encoding the Inhibitor of Apoptosis Proteins

The neural crest cell (NCC) is a multipotent progenitor cell population that is sensitive to ethanol and is implicated in the Fetal Alcohol Spectrum Disorders (FASD). Studies have shown that sulforaphane (SFN) can prevent ethanol-induced apoptosis in NCCs. This study aims to investigate whether etha...

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Bibliographic Details
Main Authors: Yihong Li, Huadong Fan, Fuqiang Yuan, Lanhai Lu, Jie Liu, Wenke Feng, Huang-Ge Zhang, Shao-Yu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
sulforaphane
ethanol
apoptosis
DNA methylation
IAP proteins
neural crest cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.622152/full

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