Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults
Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans.Thirty-one healthy participants (age 40-78, 10~male/21~female) were recruited...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-11-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00219/full |
| _version_ | 1818984176985047040 |
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| author | Jaroslav eRokicki Jaroslav eRokicki Lucia eLi Jun eKaneko Etsuko eImabayashi Tatsuhiro eHisatsune Hiroshi eMatsuda |
| author_facet | Jaroslav eRokicki Jaroslav eRokicki Lucia eLi Jun eKaneko Etsuko eImabayashi Tatsuhiro eHisatsune Hiroshi eMatsuda |
| author_sort | Jaroslav eRokicki |
| collection | DOAJ |
| description | Carnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans.Thirty-one healthy participants (age 40-78, 10~male/21~female) were recruited to a double-blind placebo-controlled study. Participants were assigned to twice-daily doses of imidazole dipeptide formula ($n = 14$), containing 500~mg (carnosine/anserine, ratio 1/3) or an identical placebo ($n = 17$). Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation. We analyzed resting state functional connectivity with the FSL fMRI analysis package. There were no differences in neuropsychological scores between the groups at baseline. After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the Default Mode Network, the Posterior Cingulate Cortex and the Right Fronto Parietal Network, as compared with the placebo group. Furthermore, there was a correlation between the extents of cognitive and neuroimaging changes. These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity changes are associated with its effects. |
| first_indexed | 2024-12-20T18:14:51Z |
| format | Article |
| id | doaj.art-31f4cd1f782d44c9b9050fefbc13f63b |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-12-20T18:14:51Z |
| publishDate | 2015-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-31f4cd1f782d44c9b9050fefbc13f63b2022-12-21T19:30:24ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652015-11-01710.3389/fnagi.2015.00219166356Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adultsJaroslav eRokicki0Jaroslav eRokicki1Lucia eLi2Jun eKaneko3Etsuko eImabayashi4Tatsuhiro eHisatsune5Hiroshi eMatsuda6National Center of Neurology and PsychiatryUniversity of BialystokImperial College LondonThe University of TokyoNational Center of Neurology and PsychiatryThe University of TokyoNational Center of Neurology and PsychiatryCarnosine and anserine are strong antioxidants, previously demonstrated to reduce cognitive decline in animal studies. We aimed to investigate their cognitive and neurophysiological effects, using functional MRI, on humans.Thirty-one healthy participants (age 40-78, 10~male/21~female) were recruited to a double-blind placebo-controlled study. Participants were assigned to twice-daily doses of imidazole dipeptide formula ($n = 14$), containing 500~mg (carnosine/anserine, ratio 1/3) or an identical placebo ($n = 17$). Functional MRI and neuropsychological assessments were carried out at baseline and after 3 months of supplementation. We analyzed resting state functional connectivity with the FSL fMRI analysis package. There were no differences in neuropsychological scores between the groups at baseline. After 3 months of supplementation, the carnosine/anserine group had better verbal episodic memory performance and decreased connectivity in the Default Mode Network, the Posterior Cingulate Cortex and the Right Fronto Parietal Network, as compared with the placebo group. Furthermore, there was a correlation between the extents of cognitive and neuroimaging changes. These results suggest that daily carnosine/anserine supplementation can impact cognitive function and that network connectivity changes are associated with its effects.http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00219/fullAgingAnserineCarnosineMemoryconnectivityDefault Mode Network |
| spellingShingle | Jaroslav eRokicki Jaroslav eRokicki Lucia eLi Jun eKaneko Etsuko eImabayashi Tatsuhiro eHisatsune Hiroshi eMatsuda Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults Frontiers in Aging Neuroscience Aging Anserine Carnosine Memory connectivity Default Mode Network |
| title | Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
| title_full | Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
| title_fullStr | Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
| title_full_unstemmed | Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
| title_short | Daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
| title_sort | daily carnosine and anserine supplementation alters verbal episodic memory and resting state network connectivity in healthy elderly adults |
| topic | Aging Anserine Carnosine Memory connectivity Default Mode Network |
| url | http://journal.frontiersin.org/Journal/10.3389/fnagi.2015.00219/full |
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