Interplay between androgen and CXCR4 chemokine signaling in myelin repair

Interplay between androgen and CXCR4 chemokine signaling in myelin repair

Abstract In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling demyelinating disorder. Testosterone has been shown to promote myelin repair. Here, we demonstrate that the cooperation between testosterone and CXCR...

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Bibliographic Details
Main Authors: Narimène Asbelaoui, Charly Abi-Ghanem, Géraldine Schlecht-Louf, Hania Oukil, The Netherlands Brain Bank, Michael Schumacher, Abdel Mouman Ghoumari
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Acta Neuropathologica Communications
Subjects:
Remyelination
Androgen receptor
Testosterone
Chemokine receptor
Astrocytes
Schwann cells
Online Access:https://doi.org/10.1186/s40478-024-01730-1

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