Genetic Variants Associated with Colorectal Adenoma Susceptibility.
BACKGROUND:Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM:To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplic...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4831735?pdf=render |
| _version_ | 1819123459792306176 |
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| author | Anna Abulí Antoni Castells Luis Bujanda Juan José Lozano Xavier Bessa Cristina Hernández Cristina Álvarez-Urturi Maria Pellisé Clara Esteban-Jurado Elizabeth Hijona Andrea Burón Francesc Macià Jaume Grau Rafael Guayta Sergi Castellví-Bel Montserrat Andreu PROCOLON research group |
| author_facet | Anna Abulí Antoni Castells Luis Bujanda Juan José Lozano Xavier Bessa Cristina Hernández Cristina Álvarez-Urturi Maria Pellisé Clara Esteban-Jurado Elizabeth Hijona Andrea Burón Francesc Macià Jaume Grau Rafael Guayta Sergi Castellví-Bel Montserrat Andreu PROCOLON research group |
| author_sort | Anna Abulí |
| collection | DOAJ |
| description | BACKGROUND:Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM:To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS:We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. RESULTS:We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. CONCLUSIONS:Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population. |
| first_indexed | 2024-12-22T07:08:41Z |
| format | Article |
| id | doaj.art-31f74295138046c88a01528f00aae889 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T07:08:41Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-31f74295138046c88a01528f00aae8892022-12-21T18:34:36ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01114e015308410.1371/journal.pone.0153084Genetic Variants Associated with Colorectal Adenoma Susceptibility.Anna AbulíAntoni CastellsLuis BujandaJuan José LozanoXavier BessaCristina HernándezCristina Álvarez-UrturiMaria PelliséClara Esteban-JuradoElizabeth HijonaAndrea BurónFrancesc MaciàJaume GrauRafael GuaytaSergi Castellví-BelMontserrat AndreuPROCOLON research groupBACKGROUND:Common low-penetrance genetic variants have been consistently associated with colorectal cancer risk. AIM:To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multiplicity (≥ 3 adenomas). METHODS:We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorectal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. RESULTS:We found that 14 of the analyzed genetic variants showed a statistically significant association with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with ≥ 17 risk alleles. CONCLUSIONS:Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a subgroup with increased risk for advanced neoplasia and/or multiplicity in the general population.http://europepmc.org/articles/PMC4831735?pdf=render |
| spellingShingle | Anna Abulí Antoni Castells Luis Bujanda Juan José Lozano Xavier Bessa Cristina Hernández Cristina Álvarez-Urturi Maria Pellisé Clara Esteban-Jurado Elizabeth Hijona Andrea Burón Francesc Macià Jaume Grau Rafael Guayta Sergi Castellví-Bel Montserrat Andreu PROCOLON research group Genetic Variants Associated with Colorectal Adenoma Susceptibility. PLoS ONE |
| title | Genetic Variants Associated with Colorectal Adenoma Susceptibility. |
| title_full | Genetic Variants Associated with Colorectal Adenoma Susceptibility. |
| title_fullStr | Genetic Variants Associated with Colorectal Adenoma Susceptibility. |
| title_full_unstemmed | Genetic Variants Associated with Colorectal Adenoma Susceptibility. |
| title_short | Genetic Variants Associated with Colorectal Adenoma Susceptibility. |
| title_sort | genetic variants associated with colorectal adenoma susceptibility |
| url | http://europepmc.org/articles/PMC4831735?pdf=render |
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