Vitamin E and Autoimmune Diseases: A Narrative Review
Autoimmune diseases are characterized by the attack of the immune system to normal tissues. Patients with autoimmune diseases usually have the deficiency of dietary factors that may be related to the etiology of these conditions. Given the role of vitamin E as a physiologic stabilizer of lysosomal...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2018-06-01
|
| Series: | Reviews in Clinical Medicine |
| Subjects: | |
| Online Access: | https://rcm.mums.ac.ir/article_10480_3b84ae1dadfe171a500df72742183fe7.pdf |
| _version_ | 1797976061932208128 |
|---|---|
| author | Zahra Rezaieyazdi Maryam Sahebari Nayyereh Saadati Mandana Khodashahi |
| author_facet | Zahra Rezaieyazdi Maryam Sahebari Nayyereh Saadati Mandana Khodashahi |
| author_sort | Zahra Rezaieyazdi |
| collection | DOAJ |
| description | Autoimmune diseases are characterized by the attack of the immune system to normal tissues. Patients with autoimmune diseases usually have the deficiency of dietary factors that may be related to the etiology of these conditions. Given the role of vitamin E as a physiologic stabilizer of lysosomal membranes, its deficiency can initiate the process of autoimmune diseases or accelerate its progress. It is supposed that vitamin E could reduce oxidative stress, which is an important factor in the pathogenesis of autoimmune diseases. The literature review is indicative of a decrease in the serum levels of vitamin E in almost all autoimmune diseases. Furthermore, there is evidence regarding the possible therapeutic value of vitamin E in the management of autoimmune diseases. Owing to the anti-inflammatory and protective effect of vitamin E against free radicals, and also its important effect on cytokines levels, this vitamin may play a powerful role in the prevention and treatment of rheumatoid arthritis, as well as joint inflammation and damage. Moreover, increased vitamin E intake might decrease the incidence and severity of certain autoimmune diseases through the regulation of the immune system. |
| first_indexed | 2024-04-11T04:45:21Z |
| format | Article |
| id | doaj.art-31f795e9cb7348beac32d6aac40a7d03 |
| institution | Directory Open Access Journal |
| issn | 2345-6256 2345-6892 |
| language | English |
| last_indexed | 2024-04-11T04:45:21Z |
| publishDate | 2018-06-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Reviews in Clinical Medicine |
| spelling | doaj.art-31f795e9cb7348beac32d6aac40a7d032022-12-27T13:07:08ZengMashhad University of Medical SciencesReviews in Clinical Medicine2345-62562345-68922018-06-0152424810.22038/rcm.2018.28244.122410480Vitamin E and Autoimmune Diseases: A Narrative ReviewZahra Rezaieyazdi0Maryam Sahebari1Nayyereh Saadati2Mandana Khodashahi3Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.Autoimmune diseases are characterized by the attack of the immune system to normal tissues. Patients with autoimmune diseases usually have the deficiency of dietary factors that may be related to the etiology of these conditions. Given the role of vitamin E as a physiologic stabilizer of lysosomal membranes, its deficiency can initiate the process of autoimmune diseases or accelerate its progress. It is supposed that vitamin E could reduce oxidative stress, which is an important factor in the pathogenesis of autoimmune diseases. The literature review is indicative of a decrease in the serum levels of vitamin E in almost all autoimmune diseases. Furthermore, there is evidence regarding the possible therapeutic value of vitamin E in the management of autoimmune diseases. Owing to the anti-inflammatory and protective effect of vitamin E against free radicals, and also its important effect on cytokines levels, this vitamin may play a powerful role in the prevention and treatment of rheumatoid arthritis, as well as joint inflammation and damage. Moreover, increased vitamin E intake might decrease the incidence and severity of certain autoimmune diseases through the regulation of the immune system.https://rcm.mums.ac.ir/article_10480_3b84ae1dadfe171a500df72742183fe7.pdfautoimmune diseasesvitamin etocopherolstocotrienols |
| spellingShingle | Zahra Rezaieyazdi Maryam Sahebari Nayyereh Saadati Mandana Khodashahi Vitamin E and Autoimmune Diseases: A Narrative Review Reviews in Clinical Medicine autoimmune diseases vitamin e tocopherols tocotrienols |
| title | Vitamin E and Autoimmune Diseases: A Narrative Review |
| title_full | Vitamin E and Autoimmune Diseases: A Narrative Review |
| title_fullStr | Vitamin E and Autoimmune Diseases: A Narrative Review |
| title_full_unstemmed | Vitamin E and Autoimmune Diseases: A Narrative Review |
| title_short | Vitamin E and Autoimmune Diseases: A Narrative Review |
| title_sort | vitamin e and autoimmune diseases a narrative review |
| topic | autoimmune diseases vitamin e tocopherols tocotrienols |
| url | https://rcm.mums.ac.ir/article_10480_3b84ae1dadfe171a500df72742183fe7.pdf |
| work_keys_str_mv | AT zahrarezaieyazdi vitamineandautoimmunediseasesanarrativereview AT maryamsahebari vitamineandautoimmunediseasesanarrativereview AT nayyerehsaadati vitamineandautoimmunediseasesanarrativereview AT mandanakhodashahi vitamineandautoimmunediseasesanarrativereview |