Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights
Medical imaging has relied on ultrasound (US) as an exploratory method for decades. Nonetheless, in cell biology, the numerous US applications are mainly in the research and development phase. In this review, we report the main effects on human or mammal cells of US induced by bulk or surface acoust...
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1166 |
| _version_ | 1797501294848507904 |
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| author | Agathe Figarol Lucile Olive Olivier Joubert Luc Ferrari Bertrand H. Rihn Frédéric Sarry Denis Beyssen |
| author_facet | Agathe Figarol Lucile Olive Olivier Joubert Luc Ferrari Bertrand H. Rihn Frédéric Sarry Denis Beyssen |
| author_sort | Agathe Figarol |
| collection | DOAJ |
| description | Medical imaging has relied on ultrasound (US) as an exploratory method for decades. Nonetheless, in cell biology, the numerous US applications are mainly in the research and development phase. In this review, we report the main effects on human or mammal cells of US induced by bulk or surface acoustic waves (SAW). At low frequencies, bulk US can lead to cell death. Under specific intensities and exposure times, however, cell proliferation and migration can be enhanced through cytoskeleton fluidization (a reorganization of the actin filaments and microtubules). Cavitation phenomena, frequencies of resonance close to those of the biological compounds, and mechanical transfers of energy from the acoustic pressure could explain those biological outcomes. At higher frequencies, no cavitation is observed. However, USs of high frequency stimulate ionic channels and increase cell permeability and transfection potency. Surface acoustic waves are increasingly exploited in microfluidics, especially for precise cell manipulations and cell sorting. With applications in diagnosis, infection, cancer treatment, or wound healing, US has remarkable potential. More mechanotransduction studies would be beneficial to understand the distinct roles of temperature rise, acoustic streaming and mechanical and electrical stimuli in the field. |
| first_indexed | 2024-03-10T03:16:20Z |
| format | Article |
| id | doaj.art-31f8f9c8058b421487fc899d0df2b69a |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:16:20Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-31f8f9c8058b421487fc899d0df2b69a2023-11-23T10:12:00ZengMDPI AGBiomedicines2227-90592022-05-01105116610.3390/biomedicines10051166Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New InsightsAgathe Figarol0Lucile Olive1Olivier Joubert2Luc Ferrari3Bertrand H. Rihn4Frédéric Sarry5Denis Beyssen6Institut FEMTO-ST, UMR CNRS 6174, Université de Bourgogne Franche-Comté, F-25030 Besançon, FranceInstitut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, FranceInstitut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, FranceInstitut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, FranceInstitut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, FranceInstitut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, FranceInstitut Jean Lamour, UMR CNRS 7198, Université de Lorraine, CNRS, IJL, F-54000 Nancy, FranceMedical imaging has relied on ultrasound (US) as an exploratory method for decades. Nonetheless, in cell biology, the numerous US applications are mainly in the research and development phase. In this review, we report the main effects on human or mammal cells of US induced by bulk or surface acoustic waves (SAW). At low frequencies, bulk US can lead to cell death. Under specific intensities and exposure times, however, cell proliferation and migration can be enhanced through cytoskeleton fluidization (a reorganization of the actin filaments and microtubules). Cavitation phenomena, frequencies of resonance close to those of the biological compounds, and mechanical transfers of energy from the acoustic pressure could explain those biological outcomes. At higher frequencies, no cavitation is observed. However, USs of high frequency stimulate ionic channels and increase cell permeability and transfection potency. Surface acoustic waves are increasingly exploited in microfluidics, especially for precise cell manipulations and cell sorting. With applications in diagnosis, infection, cancer treatment, or wound healing, US has remarkable potential. More mechanotransduction studies would be beneficial to understand the distinct roles of temperature rise, acoustic streaming and mechanical and electrical stimuli in the field.https://www.mdpi.com/2227-9059/10/5/1166ultrasoundssurface acoustic wavesmammal cellscytotoxicityproliferationmigration |
| spellingShingle | Agathe Figarol Lucile Olive Olivier Joubert Luc Ferrari Bertrand H. Rihn Frédéric Sarry Denis Beyssen Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights Biomedicines ultrasounds surface acoustic waves mammal cells cytotoxicity proliferation migration |
| title | Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights |
| title_full | Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights |
| title_fullStr | Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights |
| title_full_unstemmed | Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights |
| title_short | Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights |
| title_sort | biological effects and applications of bulk and surface acoustic waves on in vitro cultured mammal cells new insights |
| topic | ultrasounds surface acoustic waves mammal cells cytotoxicity proliferation migration |
| url | https://www.mdpi.com/2227-9059/10/5/1166 |
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