Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients
PurposeBioelectrical impedance analysis (BIA) has advantages of obtaining results quickly, safely, reproducibly, and non-invasively. Phase angle (PhA) is one of the parameter of BIA, its values represent the permeability or integrity of cell membrane. With the exception of C-reactive protein (CRP),...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1111727/full |
| _version_ | 1797900412721823744 |
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| author | Gyeo Ra Lee Eun Young Kim |
| author_facet | Gyeo Ra Lee Eun Young Kim |
| author_sort | Gyeo Ra Lee |
| collection | DOAJ |
| description | PurposeBioelectrical impedance analysis (BIA) has advantages of obtaining results quickly, safely, reproducibly, and non-invasively. Phase angle (PhA) is one of the parameter of BIA, its values represent the permeability or integrity of cell membrane. With the exception of C-reactive protein (CRP), few studies have estimated an association between PhA and these conventional biomarkers. Herein, we aimed to investigate the association between the PhA value and the conventional inflammatory markers in postoperative patients in intensive care unit (ICU). Also, the correlation between the change in PhA and the occurrence of infectious complication were determined.MethodsFrom July 2020 to February 2022, retrospective observation study conducted in 221 patients who admitted to ICU after abdominal surgery. BIA measurements and blood sampling were routinely performed the next morning. The relationship between PhA and the inflammatory markers were assessed after adjusting for age and body mass index. Univariate and multivariate logistic regression analysis was performed to examine the predisposing factors for postoperative infections.ResultsAmong 221 patients admitted to ICU after abdominal surgery, infectious complications occurred in 62 cases. CRP, procalcitonin, or presepsin levels were negatively correlated with PhA in both gender. (−0.295, −0.198 or −0.212 of partial correlation coefficients, respectively in males, and 0.313, −0.245 or −0.36 of partial correlation coefficients, respectively in females) But, white blood cell did not show significant association with PhA in both genders. For males, increased level of CRP on postoperative day 1 (POD1) was revealed as the significant predicting factor for postoperative infectious complication [odds ratio (OR): 1.184, 95% confidence interval (CI): 1.090–1.285, p < 0.001]. For females, increased Acute Physiology and Chronic Health Evaluation II score at admission (OR: 1.457, 95% CI: 1.068–1.987, p = 0.018), increased level of presepsin on (OR: 1.003, 95% CI: 1.001–1.006, p = 0.016) and decreased value of PhA on POD1 (OR: 0.980, 95% CI: 0.967–0.993, p = 0.003) were revealed as the significant predicting factors.ConclusionPhase angle obtained through BIA can be used as a predictor of infection as it shows a significant association with inflammatory markers. Phase angle measurements through BIA could improve patient prognosis after abdominal surgery through the careful observation of infections and early, appropriate treatment. |
| first_indexed | 2024-04-10T08:44:31Z |
| format | Article |
| id | doaj.art-31f929284a1643618441220d39a089ab |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T08:44:31Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-31f929284a1643618441220d39a089ab2023-02-22T08:57:08ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-02-011010.3389/fmed.2023.11117271111727Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patientsGyeo Ra LeeEun Young KimPurposeBioelectrical impedance analysis (BIA) has advantages of obtaining results quickly, safely, reproducibly, and non-invasively. Phase angle (PhA) is one of the parameter of BIA, its values represent the permeability or integrity of cell membrane. With the exception of C-reactive protein (CRP), few studies have estimated an association between PhA and these conventional biomarkers. Herein, we aimed to investigate the association between the PhA value and the conventional inflammatory markers in postoperative patients in intensive care unit (ICU). Also, the correlation between the change in PhA and the occurrence of infectious complication were determined.MethodsFrom July 2020 to February 2022, retrospective observation study conducted in 221 patients who admitted to ICU after abdominal surgery. BIA measurements and blood sampling were routinely performed the next morning. The relationship between PhA and the inflammatory markers were assessed after adjusting for age and body mass index. Univariate and multivariate logistic regression analysis was performed to examine the predisposing factors for postoperative infections.ResultsAmong 221 patients admitted to ICU after abdominal surgery, infectious complications occurred in 62 cases. CRP, procalcitonin, or presepsin levels were negatively correlated with PhA in both gender. (−0.295, −0.198 or −0.212 of partial correlation coefficients, respectively in males, and 0.313, −0.245 or −0.36 of partial correlation coefficients, respectively in females) But, white blood cell did not show significant association with PhA in both genders. For males, increased level of CRP on postoperative day 1 (POD1) was revealed as the significant predicting factor for postoperative infectious complication [odds ratio (OR): 1.184, 95% confidence interval (CI): 1.090–1.285, p < 0.001]. For females, increased Acute Physiology and Chronic Health Evaluation II score at admission (OR: 1.457, 95% CI: 1.068–1.987, p = 0.018), increased level of presepsin on (OR: 1.003, 95% CI: 1.001–1.006, p = 0.016) and decreased value of PhA on POD1 (OR: 0.980, 95% CI: 0.967–0.993, p = 0.003) were revealed as the significant predicting factors.ConclusionPhase angle obtained through BIA can be used as a predictor of infection as it shows a significant association with inflammatory markers. Phase angle measurements through BIA could improve patient prognosis after abdominal surgery through the careful observation of infections and early, appropriate treatment.https://www.frontiersin.org/articles/10.3389/fmed.2023.1111727/fullinfectioninflammatory markerintensive care unitphase anglesurgery |
| spellingShingle | Gyeo Ra Lee Eun Young Kim Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients Frontiers in Medicine infection inflammatory marker intensive care unit phase angle surgery |
| title | Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients |
| title_full | Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients |
| title_fullStr | Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients |
| title_full_unstemmed | Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients |
| title_short | Usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients |
| title_sort | usefulness of phase angle on bioelectrical impedance analysis as a surveillance tool for postoperative infection in critically ill patients |
| topic | infection inflammatory marker intensive care unit phase angle surgery |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1111727/full |
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