A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i>
Ultraviolet (UV) rays and its harmful effects have always been a concern to skin health. Sunscreen and sunblock prevent the harmful effects of UV radiation on the skin. Sun Protection Factor (SPF) is an indication of the sun-protective capacity of an ingredient. There is an ever increasing interest...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Cosmetics |
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| Online Access: | https://www.mdpi.com/2079-9284/7/1/16 |
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| author | Muhammed Majeed Shaheen Majeed Renuka Jain Lakshmi Mundkur H. R. Rajalakshmi Prachi Lad Prakriti Neupane |
| author_facet | Muhammed Majeed Shaheen Majeed Renuka Jain Lakshmi Mundkur H. R. Rajalakshmi Prachi Lad Prakriti Neupane |
| author_sort | Muhammed Majeed |
| collection | DOAJ |
| description | Ultraviolet (UV) rays and its harmful effects have always been a concern to skin health. Sunscreen and sunblock prevent the harmful effects of UV radiation on the skin. Sun Protection Factor (SPF) is an indication of the sun-protective capacity of an ingredient. There is an ever increasing interest in the cosmetic industry for developing novel functional ingredients from natural sources. The purpose of this study was to determine in-vitro and in vivo SPF of natural 90% pterostilbene extracted from the dried heartwood of <i>Pterocarpus marsupium</i> (Indian Kino). The SPF of purified pterostilbene and a formulation containing 0.4% pterostilbene was determined In Vitro using a UV spectrophotometer. Pterostilbene had an SPF of 21.73 ± 0.06, while the cream formulation had an SPF of 8.84 ± 0.01. The in vivo SPF of the 0.4% pterostilbene cream in humans was found to be 6.2 ± 1.30. Primary skin irritation tests in human subjects showed the formulation was safe and had no irritation potential. Pterostilbene was also found to have significant antioxidant activity as determined by free radical scavenging assays in vitro. These results suggest that natural pterostilbene is an antioxidant and shows SPF value both in-vitro and in the human clinical study and thus could be used as an ingredient in topical sun-protective formulations. |
| first_indexed | 2024-12-14T09:44:23Z |
| format | Article |
| id | doaj.art-31fafb71d5a54dedbeabe178bef10ded |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-12-14T09:44:23Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-31fafb71d5a54dedbeabe178bef10ded2022-12-21T23:07:41ZengMDPI AGCosmetics2079-92842020-03-01711610.3390/cosmetics7010016cosmetics7010016A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i>Muhammed Majeed0Shaheen Majeed1Renuka Jain2Lakshmi Mundkur3H. R. Rajalakshmi4Prachi Lad5Prakriti Neupane6Sami Labs Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bangalore, Karnataka 560058, IndiaSami Labs Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bangalore, Karnataka 560058, IndiaSami Labs Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bangalore, Karnataka 560058, IndiaSami Labs Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bangalore, Karnataka 560058, IndiaClinWorld Private Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bengaluru, Karnataka 560058, IndiaClinWorld Private Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bengaluru, Karnataka 560058, IndiaClinWorld Private Limited, 19/1 and 19/2, First Main, Second Phase, Peenya Industrial Area, Bengaluru, Karnataka 560058, IndiaUltraviolet (UV) rays and its harmful effects have always been a concern to skin health. Sunscreen and sunblock prevent the harmful effects of UV radiation on the skin. Sun Protection Factor (SPF) is an indication of the sun-protective capacity of an ingredient. There is an ever increasing interest in the cosmetic industry for developing novel functional ingredients from natural sources. The purpose of this study was to determine in-vitro and in vivo SPF of natural 90% pterostilbene extracted from the dried heartwood of <i>Pterocarpus marsupium</i> (Indian Kino). The SPF of purified pterostilbene and a formulation containing 0.4% pterostilbene was determined In Vitro using a UV spectrophotometer. Pterostilbene had an SPF of 21.73 ± 0.06, while the cream formulation had an SPF of 8.84 ± 0.01. The in vivo SPF of the 0.4% pterostilbene cream in humans was found to be 6.2 ± 1.30. Primary skin irritation tests in human subjects showed the formulation was safe and had no irritation potential. Pterostilbene was also found to have significant antioxidant activity as determined by free radical scavenging assays in vitro. These results suggest that natural pterostilbene is an antioxidant and shows SPF value both in-vitro and in the human clinical study and thus could be used as an ingredient in topical sun-protective formulations.https://www.mdpi.com/2079-9284/7/1/16pterostilbenepterowhite<sup>®</sup>sun protection factorspfsunscreen applicationsun uv protectionin vitroin vivoiso 24444 methodminimal erythema dose |
| spellingShingle | Muhammed Majeed Shaheen Majeed Renuka Jain Lakshmi Mundkur H. R. Rajalakshmi Prachi Lad Prakriti Neupane A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i> Cosmetics pterostilbene pterowhite<sup>®</sup> sun protection factor spf sunscreen application sun uv protection in vitro in vivo iso 24444 method minimal erythema dose |
| title | A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i> |
| title_full | A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i> |
| title_fullStr | A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i> |
| title_full_unstemmed | A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i> |
| title_short | A Randomized Study to Determine the Sun Protection Factor of Natural Pterostilbene from <i>Pterocarpus Marsupium</i> |
| title_sort | randomized study to determine the sun protection factor of natural pterostilbene from i pterocarpus marsupium i |
| topic | pterostilbene pterowhite<sup>®</sup> sun protection factor spf sunscreen application sun uv protection in vitro in vivo iso 24444 method minimal erythema dose |
| url | https://www.mdpi.com/2079-9284/7/1/16 |
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