Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer

Targeting the IGF/PI3K/mTOR pathway and AXL/YAP1/TAZ pathways in primary bone cancer

Primary bone cancers (PBC) belong to the family of mesenchymal tumors classified based on their cellular origin, extracellular matrix, genetic regulation, and epigenetic modification. The three major PBC types, Ewing sarcoma, osteosarcoma, and chondrosarcoma, are frequently aggressive tumors, highly...

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Bibliographic Details
Main Authors: Danh D. Truong, Salah-Eddine Lamhamedi-Cherradi, Joseph A. Ludwig
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Journal of Bone Oncology
Subjects:
AXL
Bone cancer
Ewing sarcoma
Osteosarcoma
Chondrosarcoma
IGF-1R
Online Access:http://www.sciencedirect.com/science/article/pii/S2212137422000094

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