Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells

Actinomycin D-Activated RNase L Promotes H2A.X/H2B-Mediated DNA Damage and Apoptosis in Lung Cancer Cells

Background: Chemotherapy is an essential component for comprehensive cancer treatment, while drug resistance usually fails therapy. DNA repair mechanism of cancer cells restrains the efficacy of therapeutics targeting DNA damage. Investigating target-inducing irreversible cell death of cancer cells...

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Bibliographic Details
Main Authors: Huijing Yin, Zhengyu Jiang, Shuoer Wang, Ping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Oncology
Subjects:
actinomycin D
RNase L
DNA damage
apoptosis
lung cancer
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01086/full

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