A Review of Effects of Atorvastatin in Radiotherapy
Radiation therapy is one of the major subsets of cancer treatments. Normal tissue toxicity and tumor cell resistance are two main obstacles during radiotherapy treatments. Toxicity to healthy tissue limits the applied dose, resulting in inadequate tumor control. On the other hand, the resistances of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Mazandaran University of Medical Sciences
2023-01-01
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| Series: | Journal of Mazandaran University of Medical Sciences |
| Subjects: | |
| Online Access: | http://jmums.mazums.ac.ir/article-1-18168-en.pdf |
| _version_ | 1827698683561377792 |
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| author | Maryam Alvandi Zahra Shaghaghi Mohammad Reza Dehbanpour Soghra Farzipour Fereshteh Talebpour Amiri |
| author_facet | Maryam Alvandi Zahra Shaghaghi Mohammad Reza Dehbanpour Soghra Farzipour Fereshteh Talebpour Amiri |
| author_sort | Maryam Alvandi |
| collection | DOAJ |
| description | Radiation therapy is one of the major subsets of cancer treatments. Normal tissue toxicity and tumor cell resistance are two main obstacles during radiotherapy treatments. Toxicity to healthy tissue limits the applied dose, resulting in inadequate tumor control. On the other hand, the resistances of cancer cells lead to increased doses of radiotherapy. Therefore, agents that can simultaneously reduce the toxicity of normal tissues and increase the sensitivity of tumor cells to radiotherapy could be a potential solution to increase the efficiency of radiotherapy during cancer treatment. Many studies have found that atorvastatin, as an HMG coenzyme A reductase (HMG-CoA) inhibitor, and protects normal tissue while sensitizing cancer cells to radiotherapy via various molecular mechanisms and signaling pathways. This review summarizes the evidence for radioprotective and radiosensitivity effects of atorvastatin in vitro and in vivo studies. |
| first_indexed | 2024-03-10T13:34:39Z |
| format | Article |
| id | doaj.art-320061cba52f4067ad6e85fa66c3de69 |
| institution | Directory Open Access Journal |
| issn | 1735-9260 1735-9279 |
| language | English |
| last_indexed | 2024-03-10T13:34:39Z |
| publishDate | 2023-01-01 |
| publisher | Mazandaran University of Medical Sciences |
| record_format | Article |
| series | Journal of Mazandaran University of Medical Sciences |
| spelling | doaj.art-320061cba52f4067ad6e85fa66c3de692023-11-21T07:40:17ZengMazandaran University of Medical SciencesJournal of Mazandaran University of Medical Sciences1735-92601735-92792023-01-0132217148168A Review of Effects of Atorvastatin in RadiotherapyMaryam Alvandi0Zahra Shaghaghi1Mohammad Reza Dehbanpour2Soghra Farzipour3Fereshteh Talebpour Amiri4 Associate Professor, Department of Nuclear Medicine and Molecular Imaging, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Assistant Professor, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran BSc in Radiology, Faculty of Paramedicine, Hamadan University of Medical Sciences, Hamadan, Iran Assistant Professor, Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran Associate Professor, Department of Anatomy, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Radiation therapy is one of the major subsets of cancer treatments. Normal tissue toxicity and tumor cell resistance are two main obstacles during radiotherapy treatments. Toxicity to healthy tissue limits the applied dose, resulting in inadequate tumor control. On the other hand, the resistances of cancer cells lead to increased doses of radiotherapy. Therefore, agents that can simultaneously reduce the toxicity of normal tissues and increase the sensitivity of tumor cells to radiotherapy could be a potential solution to increase the efficiency of radiotherapy during cancer treatment. Many studies have found that atorvastatin, as an HMG coenzyme A reductase (HMG-CoA) inhibitor, and protects normal tissue while sensitizing cancer cells to radiotherapy via various molecular mechanisms and signaling pathways. This review summarizes the evidence for radioprotective and radiosensitivity effects of atorvastatin in vitro and in vivo studies.http://jmums.mazums.ac.ir/article-1-18168-en.pdfatorvastatinoxidative stressradiotherapyradiosensitiveionizing radiationradioprotective |
| spellingShingle | Maryam Alvandi Zahra Shaghaghi Mohammad Reza Dehbanpour Soghra Farzipour Fereshteh Talebpour Amiri A Review of Effects of Atorvastatin in Radiotherapy Journal of Mazandaran University of Medical Sciences atorvastatin oxidative stress radiotherapy radiosensitive ionizing radiation radioprotective |
| title | A Review of Effects of Atorvastatin in Radiotherapy |
| title_full | A Review of Effects of Atorvastatin in Radiotherapy |
| title_fullStr | A Review of Effects of Atorvastatin in Radiotherapy |
| title_full_unstemmed | A Review of Effects of Atorvastatin in Radiotherapy |
| title_short | A Review of Effects of Atorvastatin in Radiotherapy |
| title_sort | review of effects of atorvastatin in radiotherapy |
| topic | atorvastatin oxidative stress radiotherapy radiosensitive ionizing radiation radioprotective |
| url | http://jmums.mazums.ac.ir/article-1-18168-en.pdf |
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